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Jack Leonard, Ph.D.Academic Role: Professor
Faculty Appointment(s) In:
The focus of this laboratory is the characterization of cellular and
molecular events that mediate thyroid hormone action in the brain.
Current studies include: cloning and sequencing of the plasma
membrane-bound enzyme that bioactivates thyroid hormone; determination of
the subunit structure and physiochemical properties of the enzyme
polypeptide; characterization of the internalization, sorting and
degradation pathway(s) of short-lived membrane proteins in the brain;
sequencing of a 55 kDa actin-binding protein whose interactions with actin
are hormonally regulated; characterization of the isotypes of erb-a gene
products present in cultured cerebrocortical astrocytes; identification of
cyclic nucleotide-induced gene products in cultured glial cells using
substraction cloning; and determination of the developmental programming
of cytoskeletal and integrin gene products in cultured fetal brain cells. See our research movie.
Office: S4-212
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55 Lake Avenue North Worcester, MA 01655