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Jack Leonard, Ph.D.Academic Role: ProfessorFaculty Appointment(s) and Affiliations:
Graduate School of Biomedical SciencesCellular & Molecular Physiology Graduate ProgramInterdisciplinary Graduate ProgramNeuroscience Graduate Program
Cellular and Molecular Events that Mediate Thyroid Hormone Action in the Brain
The focus of this laboratory is the characterization of cellular and molecular events that mediate thyroid hormone action in the brain. Current studies include: cloning and sequencing of the plasma membrane-bound enzyme that bioactivates thyroid hormone; determination of the subunit structure and physiochemical properties of the enzyme polypeptide; characterization of the internalization, sorting and degradation pathway(s) of short-lived membrane proteins in the brain; sequencing of a 55 kDa actin-binding protein whose interactions with actin are hormonally regulated; characterization of the isotypes of erb-a gene products present in cultured cerebrocortical astrocytes; identification of cyclic nucleotide-induced gene products in cultured glial cells using substraction cloning; and determination of the developmental programming of cytoskeletal and integrin gene products in cultured fetal brain cells. See our research movie.
Office: S4-428/lab S6-319
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55 Lake Avenue North Worcester, MA 01655