Section: Publications

Heidi Tissenbaum, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Program in Gene Function and Expression
   Program in Molecular Medicine

Other Affiliation(s):
   Interdisciplinary Graduate Program

Representative Publications

Padmanabhan, S., Mukhopadhyay, A., Narasimhan, S.D., Tesz, G., Czech, M.P. and Tissenbaum, H.A. (2009). A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 136, 939-951.

Barber, L.J., Youds, J.L., Ward, J.D., McIlwraith, M.J., O'Neil, N.J., Petalcorin, M.I., Martin, J.S., Collis, S.J., Cantor, S.B., Auclair, M., Tissenbaum, H.A., West, S.C., Rose, A.M. and Boulton, S.J. (2008) RTEL1 maintains genomic stability by suppressing homolous recombination. Cell 135, 261-271.

Mukhopadhyay, A., Deplancke, B., Walhout, A.J. and Tissenbaum, H.A. (2008). Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat. Protoc. 3, 698-709.

Mukhopadhyay, A., Pan, X., Lambright, D.G. and Tissenbaum, H.A. (2007). An endocytic pathway as a target of tubby for regulation of fat storage. EMBO Rep. 8, 974.

Mukhopadhyay, A. and Tissenbaum, H.A. (2007). Reproduction and longevity: secrets revealed by C. elegans. Trends Cell Biol. 17, 65-71.

Mukhopadhyay, A., Oh. S.W. and Tissenbaum, H.A. (2006). Signals to and from DAF-16/FOXO. Exp. Gerontol. 41, 928-934.

Wang, Y., Oh, S.W., Deplancke, B., Luo, J., Walhout, A.J. and Tissenbaum, H.A. (2006). C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech Ageing and Dev. 127, 741-747.

Deplancke, B., Mukhopadhyay, A., Ao, W., Elewa, A.E., Grove, C.A., Martinez, N.J., Sequerra, R., Doucette-Stamm, L., Reece-Hoyes, J.S., Hope, I.A., Tissenbaum, H.A., Mango, S.E. and Walhout, A.J. (2006). A gene-centered C. elegans protein-DNA interaction network. Cell 125, 1193-1205.

Oh, S.W., Mukhopadhyay, A., Dixit, B.L., Raha, T., Green, M.R. and Tissenbaum, H.A. (2006). Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation. Nat.Genet. 38, 251-257.

Wang, Y. and Tissenbaum, H.A. (2006). Overlapping and distinct functions for a C. elegans SIR2 and DAF-16/FOXO. Mech Ageing and Dev. 127, 48-56.

Grabowski, M.M., Svrizikapa, N. and Tissenbaum, H.A. (2005). Bloom syndrome ortholog HIM-6 maintains genomic stability in C. elegans. Mech Ageing and Dev. 126, 1314-1321.

Mukhopadhyay, A., Deplanke, B., Walhout, A.J.M. and Tissenbaum, H.A. (2005). C. elegans tubby regulates life span and fat storage by two independent mechanisms. Cell Metabolism 2, 35-42.

Oh, S.W., Mukhopadhyay, A., Svrzikapa, N., Jiang, F., Davis, R.J. and Tissenbaum, H.A. (2005). JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc. Natl. Acad. Sci. 102, 4494-4499.

Tissenbaum, H.A. and Guarente, L. (2002). Model organisms as a guide to mammalian aging. Dev. Cell 1, 9-19.

McVey, M., Kaeberlein, M., Tissenbaum, H. A. and Guarente, L. (2001). The short life span of S. cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics, 157, 1531-1542.

Tissenbaum, H. A. and Guarente, L. (2001). Increased dosage of a C. elegans sir-2 gene extends life span. Nature 410, 227-230.

Tissenbaum, H. A., Hawdon, J., Perregaux, M., Hotez, P., Guarente, L. and Ruvkun, G. (2000). A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Proc. Natl. Acad. Sci. 97, 460-465.

Tissenbaum, H. A. and Ruvkun, G. (1998). An Insulin-like signaling pathway affects both longevity and reproduction in Caenorhabditis elegans. Genetics 148, 703-717.

Ogg, S., Paradis, S., Gottlieb, S., Patterson, G. I., Lee, L., Tissenbaum, H. A. and Ruvkun, G. (1997). The DAF-16 Fork head-related transcription factor transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994-999.

Kimura*, K. , Tissenbaum*, H. A., Liu, Y. and Ruvkun, G. (1997). daf-2, an insulin receptor family member that regulated longevity and diapause in Caenorhabditis elegans. Science 277, 942-946.
*denotes co-first author paper

Morris*, J. Z., Tissenbaum*, H. A. and Ruvkun, G. (1996). A putative phosphatidylinositol-3-kinase regulating longevity and diapause arrest in Caenorhabditis elegans. Nature 382, 536-539.
*denotes co-first author paper

Office: 621
Phone: 508-856-5840
E-mail: Heidi.Tissenbaum@umassmed.edu
Keywords: Organisms - C. elegans, Cancer Biology, Diabetes, Aging, Genetics

More on Heidi Tissenbaum's Research Research | Figures | Publications | Rotations | Personnel | Biography View All Sections on One Page