Section: Publications

Paul D. Kaufman, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Program in Gene Function and Expression
   Program in Molecular Medicine



Representative Publications

Erkmann JA and Kaufman PD. A negatively charged residue in place of histone H3K56 supports chromatin assembly factor association but not genotoxic stress resistance. DNA Repair (Amst), in press.

Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK and Kaufman PD.  A versatile viral system for expression and depletion of proteins in mammalian Cells.  PLoS ONE 4: e6529 (2009).

Kaplan T, Liu CL, Erkmann JA, Holik J, Grunstein M, Kaufman PD*, Friedman N* and Rando OJ*. Cell cycle- and chaperone-mediated regulation of H3K56ac incorporation in yeast. PLoS Genetics 4: e1000270 (2008) (*co-corresponding authors).

Berndsen CE, Tsubota T, Lindner SE, Lee S, Holton, JM, Kaufman PD, and Keck JL and Denu JM. Molecular functions of the histone acetyltransferase chaperone complex Rtt109-Vps75.  Nat. Struct. Mol. Biol 15: 948-956 (2008). 

Tsubota T, Berndsen CE, Erkmann JA, Smith CL, Yang L, Freitas MA, Denu JM and Kaufman PD. Histone H3-K56 acetylation is catalyzed by histone chaperone-dependent complexes. Mol. Cell 25: 703-712 (2007).

Antczak AJ, Tsubota T, Kaufman PD and Berger JM. Structure of the yeast histone H3-Asf1 interaction: Implications for chaperone mechanism, species-specific interactions, and epigenetics. BMC Struct. Biol. 6: 26 (2006).

Recht J, Tsubota T, Tanny JC, Diaz RL, Berger JM, Zhang X, Garcia BA, Shabanowitz J, Burlingame AL, Hunt DF, Kaufman PD, and Allis CD. Histone chaperone Asf1 is required for acetylation of histone H3 lysine 56, a modification associated with S phase in mitosis and meiosis. Proc. Natl. Acad. Sci. USA 103: 6988-6993 (2006).

Sharp JA, Rizki G, and Kaufman PD. Regulation of histone deposition proteins Asf1/Hir1 by multiple DNA damage checkpoint kinases in S. cerevisiae. Genetics 171: 885-899 (2005).

Green EM, Antczak AJ, Bailey AO, Franco AA, Wu KJ, Yates JR, and Kaufman PD. Replication-independent histone deposition by the HIR complex and Asf1. Curr. Biol. 15: 2044-2049 (2005).

Franco AA, Lam WM, Burgers PM, and Kaufman PD.  Histone deposition protein Asf1 maintains DNA replisome integrity and interacts with Replication Factor C.  Genes Dev. 19: 1365-1375 (2005).

Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD and Adams PD.  Formation of macroH2A-containing senescence associated heterochromatin foci (SAHF) and senescence driven by ASF1a and HIRA. Dev. Cell 8:19-30 (2005).

Franco AA and Kaufman PD. Histone deposition proteins: links between the DNA replication machinery and epigenetic gene silencing.  Cold Spring Harbor Symposia on Quantitative Biology 69: 1-8 (2004).

Daganzo SM, Erzberger JP, Lam WM, Skordalakes E, Zhang R, Franco AA, Brill SJ, Adams PD, Berger JM, and Kaufman PD.  Structure and function of the conserved core of histone deposition protein Asf1. Current Biology 13: 2148-2158 (2003).

Sharp JA , Krawitz DC, Gardner KA,  Fox CA, and Kaufman PD. The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin. Genes Dev. 17: 2356-61 (2003).

Sutton A, Shia W-J, Band D, Kaufman PD, Osada S, Workman JL, and Sternglanz R. Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex.  J. Biol. Chem. 278: 16887 - 16892 (2003).

Ye X, Franco AA, Santos H, Kaufman PD, and Adams PD.  Inhibition of S-phase chromatin assembly causes DNA damage, activation of the S-phase checkpoint and S-phase arrest. Mol. Cell 11: 341-351 (2003).

Sharp JA and Kaufman PD. Chromatin proteins are determinants of centromere function. In Current Topics in Microbiology and Immunology: Protein Complexes that Modify Chromatin (ed. J.L. Workman), Vol. 274, p.23-52, Springer-Verlag Press (2003).

Formosa T, Ruone S, Adams MD, Olsen AE, Eriksson P, Yu Y, Rhoades AR, Kaufman PD, and Stillman DJ.  Defects in SPT16 or POB3 (yFACT) Cause Dependence on the Hir/Hpc Pathway: Accessing DNA May Degrade Chromatin Structure. Genetics 162: 1557-1571 (2002).

Sharp JA, Franco AA, Osley MA, and Kaufman PD.  Chromatin Assembly Factor-I and Hir proteins contribute to building functional kinetochores in Saccharomyces cerevisiae. Genes Dev. 16: 85-100  (2002).

Krawitz DC, Kama T, and Kaufman PD. Chromatin Assembly Factor-I mutants defective for PCNA binding require Asf1/Hir proteins for silencing. Mol. Cell. Biol. 22: 614-625 (2002).

Sharp JA, Fouts ET, Krawitz, DC, and Kaufman PD.  Yeast Histone Deposition Protein Asf1p Requires Hir Proteins and PCNA for Heterochromatic Silencing.  Current Biology 11: 463-473 (2001).

Kaufman PD  and Almouzni G.  DNA replication, nucleotide excision repair, and nucleosome assembly. In Chromatin Structure and Gene Expression (ed. S.C.R. Elgin and J.L. Workman), Vol. 2, p. 24-48, Oxford University Press (2000).

Game JC and Kaufman PD.  Role of Saccharomyces cerevisiae Chromatin Assembly Factor-I in repair of ultraviolet radiation damage in vivo.  Genetics 151: 485-497 (1999).

Kaufman PD, Cohen JL, and Osley MA.  Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of Chromatin Assembly Factor-I. Mol. Cell. Biol. 18: 4793-4806 (1998).

Verreault A, Kaufman PD, Kobayashi R, and  Stillman B.  Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Current Biology 8: 96-108 (1998).

Kaufman PD, Kobayashi R, and Stillman B.  Ultraviolet radiation-sensitivity and reduction of telomeric silencing in Saccharomyces cerevisiae cells lacking Chromatin Assembly Factor-I. Genes Dev. 11: 345-357 (1997).

Verreault A, Kaufman PD, Kobayashi R, and  Stillman B.  Nucleosome assembly by a  complex of Chromatin Assembly Factor-I and acetylated histones H3/H4. Cell  87: 95-104 (1996).

Gaillard P-HL, Martini EM-D, Kaufman PD, Stillman B, Moustacchi E, and Almouzni G. Chromatin assembly coupled to DNA repair: a new role for Chromatin Assembly Factor-I. Cell  86: 887-896 (1996).

Kamakaka RT, Bulger M, Kaufman PD, Stillman B, and Kadonaga JT.  Post-replicative chromatin assembly by Drosophila and Human Chromatin Assembly Factor-I.  Mol. Cell. Biol. 16: 810-817 (1996).

Kaufman PD, Kobayashi R, Kessler N, and Stillman B.  The p150 and p60 subunits of Chromatin Assembly Factor-I:  A molecular link between newly synthesized histones and DNA replication.   Cell 81: 1105-1114 (1995).

Office: LRB 506
Phone: 508-856-5016
E-mail: Paul.Kaufman1@umassmed.edu
Keywords: Organisms - vertebrate/human cell lines, Chromosome Structure & Dynamics, Protein Acetylation and Deacetylation, Biochemistry, Organisms - yeast

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