Section: Figures

Postdoctoral Position Available

Michael Green, Ph.D.,M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Program in Gene Function and Expression
   Program in Molecular Medicine

Joint Faculty In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Center for AIDS Research
   Interdisciplinary Graduate Program

The lipocalin mouse 24p3 has been implicated in diverse physiological processes, including apoptosis due to interleukin-3 (IL-3) deprivation and iron transport.  We have isolated by expression cloning a complementary DNA encoding a 24p3 cell surface receptor (24p3R).  Ectopic 24p3R expression confers on cells the ability to undergo either iron uptake or apoptosis, dependent upon the iron content of the ligand: iron-loaded 24p3 (holo-24p3) increases intracellular iron concentration withough promoting apoptosis; iron-lacking 24p3 (apo-24p3) decreases intracellular iron levels, which induces expression of the proapoptotic protein Bim, resulting in apoptosis.

Office: LRB-628
Phone: 508-856-5330
E-mail: Michael.Green@umassmed.edu
Keywords: RNA Splicing, Cancer Biology, Apoptosis, Gene Expression, Gene Regulation

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Green for additional details.