| ||Benjamin Manning|
I am interested in the biochemical means by which ATP-dependent chromatin remodeling enzymes such as yeast SWI/SNF, use the energy of ATP hydrolysis to alter the structure and composition of chromatin. Specifically, I am using a combination of biochemistry and yeast genetics to characterize novel remodeling mechanisms that SWI/SNF complex activates when its target lies within heterochromatin.
| ||Sarah Swygert|
I am interested in the structure and dynamics of yeast heterochromatin. My work involves reconstitution of Sir3 and Sir2,3,4 proteins on recombinant nucleosomal arrays and their analysis by analytical ultracentrifugation and other biophysical methods.
| ||Mayuri Rege|
As a graduate student, I am exploring a new transcriptional role for SWI/SNF that involves functional antagonism of the yeast silencing protein, SIR3, within euchromatin. My work involves extensive genetic techniques and large-scale genomic studies.
| ||Gwendolyn Bennett|
I am currently interested in the role of chromatin modifying enzymes, such as SWI/SNF and INO80, in the repair of DNA double strand breaks. Much of my work is focused on understanding their recruitment mechanisms. I received my BS from the University of New Hampshire, and also worked at a biomedical diagnostics laboratory before joining UMass.