Section: Publications

Postdoctoral Position Available

Francis Chan, Ph.D.

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Pathology

Other Affiliation(s):
   Center for AIDS Research
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Selected publications:

1. Y. Cho, S. Challa, D. Moquin, R. Genga, T.D. Ray, M. Guildford and F.K.M. Chan .  Phosphorylation-Driven Assembly of RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation.  Cell 137: 1112-1123 (2009). Pubmed Link

2. F. K. Chan .  Three is Better Than One: Pre-ligand Assembly in the Regulation of TNF Receptor Signaling.  Cytokine 37(2): 101-107 (2007). Pubmed Link

3. M. Woelfel, J. Bixby, M.A. Brehm and F. K-M. Chan .  Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.  J. Immunol. 177: 3814-3820 (2006). Pubmed Link

4. L.M. Sedger, S.R. Osvath, G. Li, X-M, Xu, F.K-M. Chan , J.W. Barrett and G. McFadden.  Poxvirus TNF-R like T2 proteins contain a conserved pre-ligand assembly domain (PLAD) that inhibits cellular TNF-R1 induced cell death.  J. Virol. 80(18): 9300-9309 (2006). Pubmed Link

5. L. Zheng, N. Bidere, D. Staudt, A. Cubre, J. Orenstein, F.K. Chan and M. Lenardo.  Competitive control of independent programs of tumor necrosis factor-induced cell death by TRADD and RIP1.  Mol. Cell. Biol., 26(9): 3505-3513 (2006). Pubmed Link

6. L. Clancy, K. Mruk, K. Archer, M. Woelfel, J. Mongkolsapaya, G. Screaton, M. J. Lenardo and F. K. M. Chan.   PLAD-mediated ligand-independent association between TRAIL receptor 4 and TRAIL receptor 2 regulates TRAIL-induced apoptosis.  Proc. Natl. Acad. Sci., 102(50): 18099-18104 (2005). Pubmed Link

7. G-M. Deng, L. Zheng, F. K. M. Chan and M. J. Lenardo.  Amelioration of inflammatory arthritis by targeting the Pre-ligand assembly domain (PLAD) of tumor necrosis factor receptors.  Nat. Med. 11(10): 1066-1072 (2005). Pubmed Link

8. F. K. M. Chan, J. Shisler, L. Zheng, J. G. Bixby, M. Felices, J. Orenstein, B. Moss and M. J. Lenardo. A Role for Tumor Necrosis Factor Receptor 2 (TNFR-2) and Receptor-interacting Protein (RIP) in Programmed Necrosis and Anti-Viral Responses.  J. Biol. Chem., 278(51): 51613-51621 (2003). Pubmed Link

9. F.K.M. Chan , H. J. Chun, L. Zheng, R. M. Siegel, K. L. Bui and M. J. Lenardo.  A Novel Domain in Tumor Necrosis Factor Receptors Mediates Pre-Ligand Receptor Assembly and Signaling.  Science, 288:2351-4 (2000). Pubmed Link

Office: S2 -125
Phone: 508-856-1664
Fax: 508-856-1665
E-mail: Francis.Chan@umassmed.edu
Keywords: Immunology, Cell Death, Cancer Biology, Autoimmunity, Viral Infections and Immunity

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Chan for additional details.