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Synthetic tissue grafts and smart implants guiding the repair and regeneration of musculoskeletal tissues
With an aging population, the demand for synthetic tissue scaffolds assisting the repair and reconstruction of musculoskeletal tissue defects resulting from trauma, aging, cancer and metabolic diseases is \rising. Our lab is interested in 1) developing new biomaterial- and stem cell-based approaches towards bone and cartilage tissue regeneration, particularly dealing with hard-to-heal tissue defects resulting from aging, diabetes, and traumatic injuries; 2) identifying novel factors regulating stem cell renewal and skeletal tissue regeneration; 3) identifying new targets for the development of disease modifying drugs of osteoarthritis; and 4) improving the osteointegration of and reducing periprosthetic infections associated with existing orthopedic metallic implants. Many of the synthetic scaffolds we designed are programmed with unique physical properties to facilitate facile surgical delivery (injectable formulations; minimally invasive in vivo deployment), tunable & predictive in vivo degradation profiles, and spatially controlled presentation and temporally controlled release of bioactive factors for regulating stem/progenitor cell fate within the tissue niche environment.
B.S. 1995, Fudan University, P.R. China
Ph.D. 1999, Michigan State University
Postdoctoral Fellow 1999-2002, University of California Berkeley & Lawrence Berkeley National Laboratory
Staff Scientist 2002-2006, Lawrence Berkeley National Laboratory
Artem Kutikov, Kevin A. Reyer and Jie Song. Shape Memory Performance of Thermoplastic Amphiphilic Triblock Copolymer poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA)/Hydroxyapatite Composites. Macromol. Chem. Phys. 2014; In press.
Jordan D. Skelly, Jeffrey Lange, Tera M. Filion, Xinning Li, David C. Ayers and Jie Song. Vancomycin-bearing synthetic bone graft delivers rhBMP-2 and promotes healing of critical rat femoral segmental defects. Clin. Orthop. Relat. Res. 2014; DOI: 10.1007/s11999-014-3841-1.
Artem B. Kutikov, Anvesh Gurijala and Jie Song. A rapid prototyped amphiphilic polymer/hydroxyapatite composite scaffold with hydration-induced self-fixation behavior. Tissue Eng. Part C: Methods. 2014; DOI: 10.1089/ten.tec.2014.0213.
Pingsheng Liu, Jordan D. Skelly and Jie Song. Three-dimensionally presented anti-fouling zwitterionic motifs sequester and enable high-efficiency delivery of therapeutic proteins. Acta Biomater. 2014; DOI: 10.1016/j.actbio.2014.06.
Pingsheng Liu, Emily Domingue, David C. Ayers and Jie Song. Modification of Ti6Al4V Substrates with Well-defined Zwitterionic Polysulfobetaine Brushes for Improved Surface Mineralization. ACS Appl. Mater. Interfaces. 201, 6(10):7141-52.
Zhang J, Song J. Amphiphilic degradable polymers for immobilization and sustained delivery of sphingosine 1-phosphate. Acta Biomater. 2014 Jul; 10(7):3079-90.
Xu J, Feng E, Song J. Bioorthogonally Cross-Linked Hydrogel Network with Precisely Controlled Disintegration Time over a Broad Range. J Am Chem Soc. 2014 Mar 19; 136(11):4105-8.
Jianwen Xu, Ellva Feng and Jie Song. Renaissance of Aliphatic Polycarbonates: New Techniques and Biomedical Applications. J Appl Polym Sci (Journal cover article). 2014; 131:39822.Tera Filion and Jie Song. A sulfated nanofibrous mesh supporting the osteogenic differentiation of periosteum-derived cells. J Biomat Tissue Eng. 2013; 3(4):1-7.
Liu P, Song J. Sulfobetaine as a zwitterionic mediator for 3D hydroxyapatite mineralization. Biomaterials. 2013 Mar; 34(10):2442-54.
Liang Zhao*, Artem Kutikov*, Jie Shen, Chunying Duan, Jie Song and Gang Han (*co-first author). Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranotics. 2013; 4(3):249-257.
Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute. Clin Orthop Relat Res. 2012 Oct 16.
Guanying Chen, Jie Shen, Tymish Y. Ohulchanskyy, Nayan Patel, Artem Kutikov, Zhipeng Li, Jie Song, Ravindra K. Pandey, Hans Ågren, Paras N. Prasad, and Gang Han. Heterogeneous (a-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging. ACS Nano. 2012; 6(9):8280–8287.
Guanying Chen, Jie Shen, Tymish Y. Ohulchanskyy, Nayan Patel, Artem Kutikov, Zhipeng Li, Jie Song, Ravindra K. Pandey, Hans Ågren, Paras N. Prasad, and Gang Han. Heterogeneous (α-NaYbF4:Tm3+)/CaF2 Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging. ACS Nano. 2012, 6 (9), 8280–8287.
Jianwen Xu and Jie Song. "Engineering Polylactic Acid with Thermal-responsive Shape Memory Effect for Medical Applications" Chapter 11, Polylactic Acid: Synthesis, Properties and Applications, Vincenzo Piemonte Ed., ISBN: 978-1-62100-348-9, Nova Science Publishers, 2012.
Jianwen Xu, Tera M. Filion, Fioleda Prifti and Jie Song. Cytocompatible Poly(ethylene glycol)-co-polycarbonate Hydrogels Crosslinked by Copper-free, Strain-promoted "Click" Chemistry. Chem-Asian J. 2011, 6 (10), 2730-2737 (Frontispiece article; special issue on the 10th anniversary of "Click" Chemistry).
Jianwen Xu and Jie Song. "Thermal responsive shape memory polymers for biomedical applications" Chapter 6, Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed., ISBN 979-953-307-309-5, InTech, 2011, pp125-142.
Tera M. Filion and Jie Song. "Scalable functional bone substitutes: strategic integration of key structural elements of bone in synthetic biomaterials" Chapter 12, Biomedical Engineering - Frontiers and Challenges, Reza Fazel Ed., ISBN 979-953-307-309-5, InTech, 2011, pp233-248.
Pingsheng Liu, Jonathan Smits, David C. Ayers and Jie Song. Surface mineralization of Ti6Al4V with calcium apatites for the retention and localized delivery of rhBMP-2. Acta Biomaterialia 2011, 7, 3488-3495.
Tera M. Filion, Artem Kutikov and Jie Song. Chemically modified cellulose fibrous meshes for use as tissue engineering scaffolds. Bioorg. Med. Chem. Lett. 2011, 21, 5067-5070.
Jianwen Xu, Fioleda Prifti and Jie Song. A Versatile Monomer for Preparing Well-Defined Functional Polycarbonates and Poly(ester-carbonates). Macromolecules, 2011, 44, 2660-2667.
Woo-Jae Chung, Ki-Young Kwon, Jie Song and Seung-Wuk Lee. Evolutionary screening of collagen-like peptides that nucleate hydroxyapatite crystals. Langmuir, 2011, 27, 7620-7628.
Tera M. Filion, Jianwen Xu, Manju L. Prasad and Jie Song. In vivo tissue responses to thermal-responsive shape memory polymer nanocomposites. Biomaterials 2011, 32, 985-991.
Tera M. Filion, Xinning Li, April Mason-Savas, Jaclynn M. Kreider, Steven A. Goldstein, David C. Ayers and Jie Song. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng. Part A 2011, 17 (3-4), 503-511.
Jianwen Xu and Jie Song. High performance shape memory polymer networks based on rigid nanoparticle cores. Proc. Natl. Acad. Sci. 2010, 107 (17), 7652-7657.
Jianwen Xu, Xinning Li, Jane B. Lian, David C. Ayers and Jie Song. Sustained and localized release of BMP-2/7, RANKL and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute J. Orthop. Res. 2009, 27 (10), 1306-1311.
James Su, Elena Iomdina, Elena Tarutta, Brian Ward, Jie Song, Christine F. Wildsoet. Effects of poly(2-hydroxyethyl methacrylate) and poly(vinyl-pyrrolidone) hydrogel implants on myopic and normal chick sclera. J. Exp. Eye Res. 2009, 88(3):445-57.
Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni P. Tomsia, Jane B. Lian, Gary S. Stein, David C. Ayers, and Carolyn R. Bertozzi. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications J. Biomed. Mater. Res. 2009, 89A (4):1098-107.
Jessica D. Kaufman, Jie Song and Catherine M. Klapperich. Nanomechanical analysis of bone tissue engineering scaffolds. J. Biomed. Mater. Res. 2007, 81A, 611-623.
Antoni P. Tomsia, Eduardo Saiz, Jie Song and Carolyn Bertozzi. Biomimetic Bonelike Composites and Novel Bioactive Glass Coatings. Adv. Eng. Mater. 2005, 7(11), 999-1004.
Jie Song, Viengkham Malathong and Carolyn R. Bertozzi. Mineralization of synthetic polymer scaffolds: A bottom-up approach for the development of artificial bone. J. Am. Chem. Soc. 2005, 127, 3366-3372.
Jie Song and Carolyn R. Bertozzi. “Functional polymers for bone tissue engineering applications” in Handbook of Nanostructured Biomaterials and Their Applications in Nanobiotechnology, H. S. Nalwa Ed., American Scientific Publishers 2005, Vol. 2 (Applications in Nanobiotechnology), pp371-392.
Jie Song, Julia Chen, Catherine M. Klapperich, Vincent Eng and Carolyn R. Bertozzi. Functional glass slides for in vitro evaluation of interactions between bone cells and mineral-binding surfaces. J. Mater. Chem. 2004, 14, 2643-2648 .
Jie Song, Justin S. Cisar and Carolyn R. Bertozzi. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J. Am. Chem. Soc. 2004, 126 (27), 8459-8465.
Quan Cheng, Shimin Zhu, Jie Song, and Na Zhang. Functional Lipid Microstructures Immobilized on a Gold Electrode for Voltammetric Biosensing of Cholera Toxin. Analyst 2004, 129 (4), 309-314.
Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. Preparation of pHEMA-CP composites with high interfacial adhesion via template-driven mineralization. J. Eur. Ceram. Soc. 2003, 23(15), 2905-2919.
Jie Song, Eduardo Saiz and Carolyn R. Bertozzi. A new approach to mineralization of biocompatible hydrogel scaffolds: An efficient process towards 3-dimensional bonelike composites. J. Am. Chem. Soc. 2003, 125 (5), 1236-1243.
Jie Song, Quan Cheng and Raymond C. Stevens. Controlling Morphologies of Self-assembling Lipids by Doping Approaches – A Transmission Electron Microscopy Study of Bolaamphiphilic Polydiacetylene Systems. Chem. Phys. Lipids 2002 114, 203-214.
Jie Song, Quan Cheng, Shimin Zhu and Raymond C. Stevens. “Smart” Materials for Biosensing Devices: Cell-Mimicking Supramolecular Assemblies and Colorimetric Detection of Pathogenic Agents. Biomedical Microdevices 2002, 4(3), 213-221.
Jie Song, Quan Cheng and Raymond C. Stevens. Modulating Artificial Membrane Morphology: A pH-Induced Chromatic Transition and Nanostructural Transformation of a Bolaamphiphilic Conjugated Polymer from Blue Helical Ribbons to Red Nanofibers. J. Am. Chem. Soc. 2001, 123, 3205-3213.
Jie Song and Rawle I. Hollingsworth. Homochiral 4-Hydroxy-5-hexenoic Acids and Their Derivatives and Homologues from Carbohydrates. Tetrahedron: Asymmetry 2001, 12, 387-391.
Jie Song and Rawle I. Hollingsworth. Synthesis, Conformational Analysis and Phase Characterization of a Versatile Self-assembling Monoglucosyl Diacylglycerol Analog. J. Am. Chem. Soc. 1999, 121, 1851-1861.
Potential Rotation Projects
1. Design and evaluation of smart synthetic bone / cartilage tissue grafts
2. Metallic implant surface modifications for reducing periprosthetic infections
3. New therapeutic targets for the development of disease modifying drugs of osteoarthritis
Federal government and non-for-profit organization:
“Osteogenic synthetic bone grafts for the repair of musculoskeletal defects”
PI: Jie Song, 2008-2013
Sponsor: NIH/NIAMS (R01AR055615)
“A nanostructured approach to complex tissue scaffolds and smart implants”
PI: Jie Song, 2009-2013
Sponsor: NIH/NIGMS (R01GM088678)
“Chondrogenic composite grafts for the repair of cartilage defects”
PI: Jie Song, 2009-2011
Sponsor: NIH/NIAMS (R21AR056866)
"Synthetic periosteal tissue microenvironment enhancing the repair of critical-sized long bone defects”
PI: Jie Song, 2010-2013
Sponsor: DOD/CDMRP (OR090043)
“VivaCT 75 High Speed in vivo MicroCT Scanner”
PI: Jie Song, 2010-2011
Sponsor: NIH/NCRR (1S10RR027082)
Musculoskeletal Transplant Foundation