Dagmar Ringe, Ph.D.
Harold and Bernice Davis Professor of Aging and Neurodegenerative Disease Research
Adjunct Professor of Neurology
Harvard Medical School and Brigham & Women’s Hospital
Lab website: http://www.bio.brandeis.edu/prLab/
Professor Ringe’s research interests range from structural studies of enzyme mechanisms to the basis of molecular recognition to the biochemistry of neurodegenerative diseases. She has also made important contributions in the areas of bioinformatics and rational drug design. Her approach is to bring the perspective of a physical organic chemist to problems in biochemistry, cell biology, and human health. Her primary research tools are: protein X-ray crystallography, computational biophysics, site-directed mutagenesis, organic synthesis and enzyme kinetics.
List of key papers
Auclair JR, Boggio KJ, Petsko GA, Ringe D, Agar JN.
Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis.
Proc Natl Acad Sci U S A. 2010 Nov 22.
Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, Clark LN, Small SA.
Polyamine pathway contributes to the pathogenesis of Parkinson disease.
Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16970-5.
Ringe D, Petsko GA.
What are pharmacological chaperones and why are they interesting?
J Biol. 2009 Oct 13;8(9):80.
Landon MR, Lieberman RL, Hoang QQ, Ju S, Caaveiro JM, Orwig SD, Kozakov D, Brenke R, Chuang GY, Beglov D, Vajda S, Petsko GA, Ringe D.
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase.
J Comput Aided Mol Des. 2009 Jun 12.
Lieberman RL, D'aquino JA, Ringe D, Petsko GA.
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Biochemistry. 2009 Jun 9;48(22):4816-27.
Lieberman RL, Wustman BA, Huertas P, Powe AC Jr, Pine CW, Khanna R, Schlossmacher MG, Ringe D, Petsko GA.
Structure of acid beta-glucosidase with pharmacological chaperone provides insight into Gaucher disease.
Nat Chem Biol. 2007 Feb;3(2):101-7.
Das C, Hoang QQ, Kreinbring CA, Luchansky SJ, Meray RK, Ray SS, Lansbury PT, Ringe D, Petsko GA.
Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1.
Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4675-80.
Zhou W, Zhu M, Wilson MA, Petsko GA, Fink AL.
The oxidation state of DJ-1 regulates its chaperone activity toward alpha-synuclein.
J Mol Biol. 2006 Mar 3;356(4):1036-48.
Canet-Avilés RM, Wilson MA, Miller DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR.
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization.
Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):9103-8.