2016 RESEARCH

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UMMS-led discovery of ALS gene funded by Ice Bucket Challenge; nets global attention

UMMS-led discovery of ALS gene funded by Ice Bucket Challenge; nets global attention

The discovery of a new gene implicated in ALS, led by UMMS scientist Jon Landers, PhD, and funded by The ALS Association with donations from the 2014 ALS Ice Bucket Challenge, has garnered extensive media coverage and validated the success of the social media phenomenon.

UMMS researcher finds microglia contribute to end stages of Rett Syndrome

UMMS researcher finds microglia contribute to end stages of Rett Syndrome

Dorothy P. Schafer, PhD, assistant professor of neurobiology, and colleagues have discovered a possible link between microglia function and the end stages of Rett Syndrome in animal models. This finding could be therapeutically relevant in that targeting microglia in the late stages of Rett could potentially improve function and later life outcomes.

New gene variants present in 3 percent of all ALS patients

New gene variants present in 3 percent of all ALS patients

John Landers, PhD, led a team of more than 80 scientists who found that variations in a gene with multiple functions in neurons are present in approximately 3 percent of all cases of ALS in North American and European populations, both sporadic and familial.

UMMS researchers make ‘startling’ discovery that a Salmonella protein reduces drug resistance in tumors

UMMS researchers make ‘startling’ discovery that a Salmonella protein reduces drug resistance in tumors

Scientists at UMass Medical School have found that the Salmonella protein SipA naturally reduces a well-known drug-resistant molecule found in many different types of cancer cells. They collaborated to deploy a SipA ‘nanobug’ that rendered tumors ‘almost undetectable.’

NIH study builds on previous UMMS research into chemoresistance in breast, ovarian cancer

NIH study builds on previous UMMS research into chemoresistance in breast, ovarian cancer

A new NIH study published in Nature, based on research by Sharon Cantor, PhD, helps scientists better understand how hereditary breast and ovarian cancer genes function in the repair of broken DNA. Members of Dr. Cantor’s lab contributed to the study.

Dekker, colleagues at Curie Institute untangle Barr body of inactive X chromosome

Dekker, colleagues at Curie Institute untangle Barr body of inactive X chromosome

Job Dekker, PhD, and scientists at Institut Curie in Paris and Stanford University have taken a detailed look inside the small, densely packed structure of the inactive X chromosome found in female mammals called the Barr body.

Third Rock Ventures launches Fulcrum Therapeutics; Michael Green of UMMS a co-founder

Third Rock Ventures launches Fulcrum Therapeutics; Michael Green of UMMS a co-founder

Michael Green, MD, PhD, is one of five scientific co-founders of Fulcrum Therapeutics, a new company located in Cambridge’s Kendall Square focused on discovering and developing small molecules that modulate the on/off control mechanisms that regulate genes.

Kamber Kaya and Hall representing women in science at The Allied Genetics Conference

Kamber Kaya and Hall representing women in science at The Allied Genetics Conference

GSBS student Hatem Elif Kamber Kaya was honored to have two speaking engagements at The Allied Genetics Conference, the annual national meeting of the Genetics Society of America. 

UMMS researchers discover novel link between immune system, social behavior

UMMS researchers discover novel link between immune system, social behavior

Vladimir Litvak, PhD, and colleagues made a startling discovery that immune system signaling can directly affect social behavior. Published in Nature, these findings could have great implications for neurological diseases such as autism-spectrum disorders and schizophrenia.

Meyers Primary Care Institute celebrates 20 years

Meyers Primary Care Institute celebrates 20 years

For 20 years the Meyers Primary Care Institute—a unique partnership between UMass Medical School, Fallon Health and Reliant Medical Group—has quietly improved population health through research and education.

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