Expert’s Corner: Bosco on identifying ALS toxic proteins

By Bryan Goodchild and Mark Shelton

UMass Medical School Communications

May 02, 2012

Daryl A. Bosco, PhD, assistant professor of neurology and a protein chemist investigating the causes of amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease), talks about research at UMMS that identifies the toxic proteins that cause the disease and how that work indicates new therapeutic directions for ALS research, including RNA interference, immunotherapy and the search for small molecules that might target the rogue proteins.

“All neurodegenerative diseases are devastating, but especially ALS—it is such a drastic and severe disease,” said Dr. Bosco.