Section: Research

David Ullman, Ph.D.

Other Affiliation(s):
   Biochemistry and Molecular Pharmacology
   Program in Neuroscience
   Shriver Center

Glycoconjugates in neuropathology and neuroprotection

Research in Dr. Ullman’s laboratory focuses on the function of glycoconjugates in two diverse areas: fetal alcohol syndrome (FAS) and neuroprotection.

Cerebellar development is altered by ethanol and in vitro and in vivo studies in this laboratory suggest that disturbances in glycoconjugate levels, possibly incurred by ethanol-induced changes in retinoic acid, may contribute to ethanol-related cerebellar pathology in FAS.

A second project is focused on the possibility that derivatives of naturally occurring glycoconjugates, such as gangliosides, may effectively protect neuronal populations from cell death in the central nervous system that has been exposed to toxins or afflicted with neurodegenerative disorders such as Parkinson’s disease or Alzheimer’s disease.

Ongoing Projects

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