Section: Publications

José Lemos, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Physiology

Other Affiliation(s):
   Biochemistry and Molecular Pharmacology
   Program in Neuroscience

Selected Publications

Troadec, J.D., Thirion, S., Nicaise, G., Lemos, J.R.,  and Dayanithi, G. (1998)  The effects of ATP on intracellular Ca²⁺ and vasopressin release from isolated rat neurohypophysial terminals.   J. Physiol.,511: 89-103.

Wang, G., Dayanithi, G., Newcomb, R., and Lemos, J.R. (1999)  R-type Calcium current in rat neurohypophysial nerve terminals preferentially controls oxytocin secretion.  J. Neurosci., 19(21): 9235-9241.

Jungnickel, M.K., Marrero, H., Birnbaumer, L., Lemos, J.R., and Florman, H.M. (2001)  Trp2 regulates the Ca²⁺ entry into mouse sperm triggered by egg ZP3.  Nature Cell Biology 3(5): 199-202.

Bourinet, E., Stotz, S., Spaetgens, R., Dayanithi, G., Lemos, J., Nargeot, J., and Zamponi, G. (2001) Interaction of SNX-482 with domains II and IV inhibits activation gating of alpha 1E calcium channels. Biophys. J., 81: 79-88.

Yin, Y., Dayanithi, G., and Lemos, J.R. (2002)  Ca²⁺-regulated, synaptophysin-like channel involved in release from nerve terminals.  J. Physiol., 539.2: 409-418.

Wang, G., Dayanithi, G., Custer, E., and Lemos, J.R. (2002)  ATP acts through A1-receptor to inhibit only the N-type calcium current and corresponding peptide release from neurohypophysial nerve terminals.  J. Physiol., 540.3: 791-802.

Marrero, H.G. and Lemos, J.R.   (2003)  Loose-Patch Clamp Currents from the Hypothalamoneuro-hypophysial System of the Rat.  Pflugers Archiv (Euro. J. Physiol.), 446(6): 702-713.

Ortiz-Miranda, S., Dayanithi, G., Coccia, V.J., Custer, E., Alphandery, S., Mazuc, E., Treistman, S.N., and Lemos, J.R.   (2003)  μ-Opioid receptor modulates secretion from rat neurohypophysial terminals by inhibiting calcium influx.  J. Neuroendocr., 15: 888-894.

DeCrescenzo, V., ZhuGe, R., Velazquez-Marrero, C., Lifshitz, L.M., Custer, E., Carmichael, J., Lai, A., Tuft, R.A., Fogarty, K.E., Lemos J.R., and Walsh, Jr., J.V. (2004)  Ca²⁺ syntillas, miniature Ca²⁺ release events in terminals of hypothalamic neurons are increased in frequency by depolarization in the absence of Ca²⁺ influx.  J. Neurosci., 24(5): 1226-1235.

McNally, J.M., Woodbury, D.J., and Lemos, J.R.   (2004)  Syntaxin 1a Is Sufficient to Cause Spontaneous Fusion of  Bovine Neurosecretory Granules to a Planar Lipid Bilayer.  Cell Bioch. & Biophys., 41(1):11-23.

Pietrzykowski, A., Martin, G., Knott, T., Puig, S., Lemos, J.R., and Treistman, S.N. (2004)  Alcohol Tolerance in BK Channels of Neuronal Terminals is Intrinsic and Includes Two Components: Decreased Channel Sensitivity to Ethanol and Decreased Channel Density.    J. Neurosc., 24:8322-8332.

Marrero, H. and Lemos, J.R.  (2005) Calcium and Potassium Channels Affect the Frequency‑Dependence of Voltage‑Activated Responses from the Rat Neurohypophysis.  Pflugers Archiv, 450(2): 96-110.

Knott, T.K., Velazquez-Marrero, C., and Lemos, J.R.   (2005)  ATP elicits inward currents in isolated vasopressinergic Neurohypophysial terminals via P2X₂ and P2X₃ receptors.  Pflugers Archiv, 450:381-389.

Zhuge, R., Decrescenzo, V., Sorrentino, V., Lai, T., Tuft, R.A., Lifshitz, L., Lemos, J.R.,  Smith, C., Fogarty, K.E. and  Walsh, J.V.  (2006) Syntillas release Ca²⁺ at a site different from the microdomain where exocytosis occurs in mouse chromaffin cells. Biophys. J., 90:2027-2037 (doi:10.1529/biophysj.105.071654)

Decrescenzo, V., Fogarty, K.E,, Zhuge, R., Tuft, R.A., Lifshitz, L., Carmichael, J.,  Bellve, K.D., Baker, S.P., Zissimopoulos, S., Lai, F.A., Lemos, J.R. and  Walsh, J.V. (2006) "Dihydropyridine receptors and Type 1 ryanodine receptors constitute the molecular machinery for Voltage-Induced Calcium Release in nerve terminals." J.Neurosci., 26: 7565-7574.

Knott, T.K., Marrero, H., Fenton, R., Custer, E., Dobson, J. and Lemos, J.R. (2007) Endogenous adenosine inhibits CNS terminal Ca²⁺ currents and exocytosis. J. Cell. Phys., 210: 309-314. (DOI:10.1002/jcp.20827)

Marrero, H.G. and Lemos, J.R. (2007) “Loose-Patch Clamp Method”. Neuromethods, vol. 38, Chapter 11 in Patch-Clamp Analysis: Advanced Techniques (2^nd edition), Wolfgang Walz, Editor, Humana Press, Pp. 325-352.

Woodbury, D.J., McNally, J.M. and Lemos, J.R.  (2007) “SNARE-induced fusion of vesicles to a planar bilayer”. chapter 10  In Advances in planar lipid bilayers and liposomes", A. Leitmannova-Liu (editor), Elsevier Press,5:285-311.

Custer, E.E., Ortiz-Miranda, S.I., Knott, T., Rawson, R., Elvey, C., Lee, R.H., and Lemos, J.R. (2007) Identification of the Neuropeptide Content of Individual Rat Neurohypophysial Terminals. Journal Neuroscience Methods  163: 226–234. (doi:10.1016/j.jneumeth.2007.03.006).

Knott, T.K., Marrero, H., Custer, E., and Lemos, J.R. (2008)  Endogenous ATP potentiates only vasopressin secretin fromneurohypophysial terminals.  J. Cell. Physiol.  217(1):155-161.  [Epub ahead of print] PMID:  18481265 [PubMed - as supplied by publisher]. (doi: 10.1002/jcp.21485).

Office: S4-137
Phone: 508-856-8567
Fax: 508-856-5997
E-mail: Jose.Lemos@umassmed.edu
Keywords: Neurobiology, Biophysics, Pharmacology

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