Section: Publications

Postdoctoral Position Available

Vivian Budnik, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Neurobiology

Other Affiliation(s):
   Interdisciplinary Graduate Program
   Program in Neuroscience

Representative Publications

Chai A, Withers J, Koh Y-H,  Parry K, Bao H, Zhang B, Budnik V,  and Pennetta G. (2007) hVAPB, the causative gene of a heterogeneous group of motor neuron diseases in humans, is functionally interchangeable with its Drosophila homologue DVAP-33A at the Neuromuscular Junction. Human Molec Genet (in press)

Li J, Ashley J, Budnik V and Bhat  MA (2007) Crucial Role of Drosophila Neurexin in Proper Active Zone Apposition to Postsynaptic Densities, Synaptic Growth and Synaptic Transmission. Neuron 55:741-755. Senior authors contributed equally to the work.

Speese, S. D., and Budnik, V. (2007). Wnts: up-and-coming at the synapse. Trends Neurosci 30, 268-275. 

Gorczyca, D., Ashley, J., Speese, S., Gherbesi, N., Thomas, U., Gundelfinger, E., Gramates, L. S., and Budnik, V. (2007). Postsynaptic membrane addition depends on the Discs-Large-interacting t-SNARE Gtaxin. J Neurosci 27, 1033-1044.

Ataman, B., Ashley, J., Gorczyca, D., Gorczyca, M., Mathew, D., Wichmann, C., Sigrist, S.J., and Budnik, V. (2006). Nuclear trafficking of Drosophila Frizzled-2 during synapse development requires the PDZ protein dGRIP. Proc Natl Acad Sci U S A 103, 7841-7846.  

Mathew, D., Ataman, B., Chen, J., Zhang, Y., Cumberledge, S., and Budnik, V. (2005). Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. Science 310, 1344-1347.

Ashley, J., Packard, M., Ataman, B., and Budnik, V. (2005). Fasciclin II signals new synapse formation through amyloid precursor protein and the scaffolding protein dX11/Mint. J Neurosci 25, 5943-5955.

Ruiz-Canada C, Ashley J, Moeckel-Cole S, , Drier E, Yin J, and Budnik V. New Synapse Formation      Disrupted by Misregulation of icrotubule Stability in aPKC Mutants. Neuron 42, 567-80.

Mathew D, Popescu A, and Budnik V (2003) Drosophila Amphiphysin functions during synaptic Fasciclin II membrane cycling. J. Neurosci 23:10710-6

Packard M, Mathew D, and Budnik V (2003) FASt remodeling of synapses in Drosophila. Curr Op Neurobiol 13:527-34.

Packard M, Matthew D, and Budnik V (2003) Wnts and TGFb in synaptogenesis: old friends signalling at new places. Nat Rev Neurosci. 4:113-20

Packard M, Koo ES, Gorczyca M, Sharpe J, Cumberledge S, and Budnik V Budnik, V. (2002). The Drosophila wnt, wingless, provides an essential signal for pre- and postsynaptic differentiation. Cell 111: 319-330.

Roche J, Packard M, Moeckel-Cole S, and Budnik V (2002). Regulation of synaptic plasticity and synaptic vesicle dynamics by the PDZ protein Scribble. J. Neurosci. 22: 6471-6479.

Mathew D, Gramates LS, , Packard M, Gorczyca M, Bilder D, Perrimon N, and Budnik V (2002). GUK-holder, a Novel Synaptic Protein that Links the Tumor Suppressors Discs-large and Scribble. Current Biol. 12: 531-539.

Koh Y-H, Ruiz-Canada C, and Budnik V (2002). The Ras1-mitogen activated protein kinase signal transduction pathway regulates synaptic plasticity through fasciclin II-mediated cell adhesion J. Neurosci. 22: 2496-2504.

Koh Y-H, Popova E, Thomas U, Griffith L, and Budnik,V (1999). Regulation of DLG localization at synapses by CaMKII-Dependent Phosphorylation. Cell 98: 353-363.

Zhang B, Koh Y-H, Beckstead RB, Budnik V, Ganetzky B, and Bellen HJ (1998). Vesicle size and number are regulated by a novel synaptic protein required for endocytosis. Neuron 21: 1465-1475.

Thomas U, Kim E, Kuhlendahl S, Koh Y, Gundelfinger ED, Sheng M, Garner CC, and Budnik V (1997). Synaptic Clustering of the Cell Adhesion Molecule Fasciclin II by Discs Large and its Role in the Regulation of Presynaptic Structure. Neuron 19: 787-799.

Budnik V, Koh YH, Guan B, Haugh C, Woods D, and Gorczyca M (1996). Regulation of synapse structure and function by the Drosophila tumor suppressor gene, dlg. Neuron 17: 627-640.

Tejedor, F.J., Bokhari, O., Rogero, O., Gorczyca, M., Zhang, J., Kim, E., Sheng, M., and Budnik, V. (1996). Essential Role for dlg in Synaptic Clustering of Shaker K+ Channels in vivo. J. Neurosci. 17: 152-159.

Office: 703
Phone: 508-856-4341
E-mail: Vivian.Budnik@umassmed.edu

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Budnik for additional details.