Section: Publications

Postdoctoral Position Available

Mark Alkema, Ph.D.

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Neurobiology

Other Affiliation(s):
   Program in Neuroscience

Representative Publications

Alkema MJ, Hunter-Ensor M, Ringstad N, Horvitz HR (2005)  Tyramine functions independently of octopamine in the Caenorhabditis elegans nervous system. Neuron 46: 247-260.

Akasaka T, van Lohuizen M, van der Lugt N, Mizutani-Koseki Y, Kanno M, Taniguchi M, Vidal M, Alkema M, Berns A, Koseki H.  Mice doubly deficient for the Polycomb Group genes Mel18 and Bmi1 reveal synergy and requirement for maintenance but not initiation of Hox gene expression. Development. 2001 May;128(9):1587-97.

Bel S, Core N, Djabali M, Kieboom K, Van der Lugt N, Alkema MJ, Van Lohuizen M.            Genetic interactions and dosage effects of Polycomb group genes in mice. Development. 1998 Sep;125(18):3543-51.

Alkema MJ, Jacobs J, Voncken JW, Jenkins NA, Copeland NG, Satijn DP, Otte AP, Berns A, van Lohuizen M.  MPc2, a new murine homolog of the Drosophila polycomb protein is a member of the mouse polycomb transcriptional repressor complex.  J Mol Biol. 1997 Nov 14;273(5):993-1003.

Alkema MJ, Jacobs H, van Lohuizen M, Berns A.  Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. Oncogene. 1997 Aug 18;15(8):899-910.

Satijn DP, Gunster MJ, van der Vlag J, Hamer KM, Schul W, Alkema MJ, Saurin AJ, Freemont PS, van Driel R, Otte AP.  RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.  Mol Cell Biol. 1997 Jul;17(7):4105-13.

Gunster MJ, Satijn DP, Hamer KM, den Blaauwen JL, de Bruijn D, Alkema MJ, van Lohuizen M, van Driel R, Otte AP. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.  Mol Cell Biol. 1997 Apr;17(4):2326-35.

Alkema MJ, Bronk M, Verhoeven E, Otte A, van 't Veer LJ, Berns A, van Lohuizen M.           Identification of Bmi1-interacting proteins as constituents of a multimeric mammalian polycomb complex.  Genes Dev. 1997 Jan 15;11(2):226-40.

van der Lugt NM, Alkema M, Berns A, Deschamps J.  The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.  Mech Dev. 1996 Aug;58(1-2):153-64.

Alkema MJ, van der Lugt NM, Bobeldijk RC, Berns A, van Lohuizen M.  Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.  Nature. 1995 Apr 20;374(6524):724-7.

Berns A, van der Lugt N, Alkema M, van Lohuizen M, Domen J, Acton D, Allen J, Laird PW, Jonkers J.  Mouse model systems to study multistep tumorigenesis. Cold Spring Harb Symp Quant Biol. 1994;59:435-47.

Alkema MJ, Wiegant J, Raap AK, Berns A, van Lohuizen M.  Characterization and chromosomal localization of the human proto-oncogene BMI-1.  Hum Mol Genet. 1993 Oct;2(10):1597-603.

Winter AJ, Alkema MJ, Groot Koerkamp MJ, van der Horst G, Mul Y, Tabak HF.  Interlocked circle formation by group I introns: structural requirements and mechanism.  Nucleic Acids Res. 1993 Jul 11;21(14):3217-26.

Verrijzer CP, Alkema MJ, van Weperen WW, Van Leeuwen HC, Strating MJ, van der Vliet PC.  The DNA binding specificity of the bipartite POU domain and its subdomains.  EMBO J. 1992 Dec;11(13):4993-5003.

Office: 717
Phone: 508-856-6158
E-mail: Mark.Alkema@umassmed.edu
Keywords: Neurobiology, Organisms - C. elegans, Learning and Memory, Neuromodulation , Genetics

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Mark Alkema for additional details.