Section: Figures

Postdoctoral Position Available

Michael Francis, Ph.D.

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Neurobiology

Joint Faculty In:
   Program in Neuroscience

Figure 1.  Schematic of the simplified C. elegans locomotory circuit.  Stimuli such as light touch to the tip of the nose initiate an avoidance response in C. elegans.  Sensory neurons make synaptic contacts onto forward/backward command interneurons that make synaptic contacts onto A and B motor neurons, initiating either forward or backward movement.

Figure 2.  Whole-cell patch clamp current recordings from C. elegans body wall muscle.  Current responses to application of acetylcholine in wild-type worms include 2 components that can be separated pharmacologically using the selective drugs levamisole and nicotine.  unc-29 mutants lack current responses to levamisole while acr-16 mutants lack current responses to nicotine.  unc-29;acr-16 double mutants show a complete lack of excitatory current in body wall muscle.

Office: 715
Phone: 508-856-1496
E-mail: Michael.Francis@umassmed.edu
Keywords: Neurobiology, Organisms - C. elegans, Electrophysiology, Genetics, Synapses

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Francis for additional details.