Section: Figures

Postdoctoral Position Available

Lab Page Link

William Theurkauf, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Program in Molecular Medicine

Other Affiliation(s):
   Biochemistry and Molecular Pharmacology
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Figure Legend

Mutations in the Drosophila scrambled locus disrupt mitotic actin organization and function. Drosophila embryogenesis is initiated by 13 rapid nuclear divisions that proceed without cytokinesis. During the final four syncytial divisions, when most of the nuclei are in a monolayer at the surface of the embryo, actin (green) associates with membrane furrows that surround the mitotic spindles (red). In scrambled mutant embryos, the actin furrows do not form and interactions between neighboring spindles lead to chromosome segregation errors. To define the molecular mechanisms that drive actin reorganization, we are using genetic and biochemical techniques to identify proteins that function with scrambled during mitotic furrow assembly.

Office: Bio4 312E
Phone: 508-856-4900
E-mail: William.Theurkauf@umassmed.edu
Keywords: Genetic Systems, Cancer Biology, Developmental Biology

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Theurkauf for additional details.