Section: Rotations

Postdoctoral Position Available

Dannel McCollum, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Rotation Projects

Little is known about how the SID pathway monitors mitosis to ensure that cytokinesis is not initiated until mitosis is complete. We have begun to examine the function of homologs of the SID pathway genes in animal cells using RNA interference (RNAi) to disrupt their function. A potential project, would be to disrupt the function of one of the SID pathway genes and characterize its function in animal cells. We have also carried out a genetic suppressor screen to identify potential inhibitors of the SID pathway, and another potential project would be to characterize and clone one of these SID pathway inhibitory genes. A new project in the lab has involved characterization of a highly conserved protein phosphatase, which we have shown is required to inhibit progression into the next cell cycle if cytokinesis is incomplete. One project could involve examination of how this phosphatase inhibits cell cycle progression using biochemical and cytological approaches.

Office: Biotech4 Suite 332
Phone: 508-856-8767
E-mail: Dannel.McCollum@umassmed.edu
Keywords: Cancer Biology, Cell Biology, Cell Cycle

More on Dannel McCollum's Research Research | Figures | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. McCollum for additional details.