Section: Publications

Allan Jacobson, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Recent Publications

Amrani N, Ghosh S, Mangus DA, Jacobson A.  Translation factors promote the formation of two states of the closed-loop mRNP. Nature, 2008 [Epub ahead of print]   Pubmed Link

Johansson MJ, He F, Spatrick P, Li C, Jacobson A.  Association of yeast Upf1p with direct substrates of the NMD pathway. Proc. Natl. Acad. Sci. U S A. 207: 20872-20877, 2007 Epub 2007 Dec 17.   Pubmed Link

Welch EM, etal, PTC124 targets genetic disorders caused by nonsense mutations.  Nature. 447: 87-91, 2007  Epub 2007 Apr 22.   Pubmed Link

Dong S, Li C, Zenklusen D, Singer RH, Jacobson A, He F. YRA1 autoregulation requires nuclear export and cytoplasmic Edc3p-mediated degradation of its pre-mRNA. Molec. Cell. 25: 559-573, 2007 Pubmed Link

Gaba A, Jacobson A, Sachs MS. Ribosome occupancy of the yeast CPA1 upstream open reading frame termination codon modulates nonsense-mediated mRNA decay.  Molec. Cell. 11: 449-460, 2005  Pubmed Link

Amrani N, Ganesan R, Kervestin S, Mangus DA, Ghosh S, Jacobson A.,A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay. Nature. 432:112-118, 2004. Pubmed Link

Ross PL, Huang YN, Marchese JN, Williamson B, Parker K, Hattan S, Khainovski N, Pillai S, Dey S, Daniels S, Purkayastha S, Juhasz P, Martin S, Bartlet-Jones M, He F, Jacobson A, Pappin DJ.  Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Molec. Cell Proteomics. 3:1154-1169, 2004. Epub 2004 Sep 22.  Pubmed Link

Mangus DA, Evans MC, Agrin NS, Smith M, Gongidi P, Jacobson A  Positive and negative regulation of poly(A) nuclease. Molec. Cell Biol. 24: 5521-5533, 2004. Pubmed Link

Mangus DA, Smith MM, McSweeney JM, Jacobson A. Identification of factors regulating poly(A) tail synthesis and maturation. Molec. Cell Biol. 24: 4196-206, 2004. Pubmed Link

Parker KC, Patterson D, Williamson B, Marchese J, Graber A, He F, Jacobson A, Juhasz P, Martin S. Depth of proteome issues: a yeast isotope-coded affinity tag reagent study. Molec. Cell Proteomics. 3: 625-659, 2004. Epub 2004 Mar 28. Pubmed Link

He F, Li X, Spatrick P, Casillo R, Dong S, Jacobson A.  Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeast.   Molec. Cell. 12:  1439-1452, 2003 Pubmed Link

Mangus DA, Evans MC, Jacobson A.  Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression.  Genome Biol. 4: 223. Epub 2003 Jul 1. Review. Pubmed Link

Maderazo AB, Belk JP, He F, Jacobson A.  Nonsense-containing mRNAs that accumulate in the absence of a functional nonsense-mediated mRNA decay pathway are destabilized rapidly upon its restitution. Molec. Cell Biol. 23:   842-851, 2003. Pubmed Link

Sachs MS, Wang Z, Gaba A, Fang P, Belk J, Ganesan R, Amrani N, Jacobson A. Toeprint analysis of the positioning of translation apparatus components at initiation and termination codons of fungal mRNAs. Methods. 26: 105-114, 2002. Pubmed Link

Düvel K, Valerius O, Mangus DA, Jacobson A, Braus GH.  Replacement of the yeast TRP4 3' untranslated region by a hammerhead ribozyme results in a stable and efficiently exported mRNA that lacks a poly(A) tail.  RNA. 8: 336-44, 2002  Pubmed Link

He, F. and Jacobson, A. Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs Molec. Cell. Biol. 21: 1515-1530, 2001.   Pubmed Link

Maderazo, A.B., He, F., Mangus, D.A., and Jacobson, A. Upf1p control of nonsense mRNA translation is regulated by Nmd2p and Upf3p. Molec. Cell. Biol. 20: 4591-4603, 2000. Pubmed Link

Review Articles

Wu C, Amrani N, Jacobson A, Sachs MS.  The use of fungal in vitro systems for studying translational regulation. (Review)  Methods Enzy. Molec. 429: 2007;203-225,2007 Pubmed Link

Amrani N, Sachs MS, Jacobson A. Early nonsense: mRNA decay solves a translational problem. Nat Rev Molec. Cell Biol. 7: 415-425, 2006. Review. Pubmed Link

Jacobson, A. The end justifies the means.  Nature Struct. Molec. Biol. 12: 474-475, 2005. Pubmed Link

Jacobson, A. Regulation of mRNA decay: decapping goes solo. Molec. Cell 15: 1-2, 2004. Pubmed Link

Mangus, D.A., Evans, M.C., and Jacobson, A. Poly(A)-binding proteins: multifunctional scaffolds for the post-transcriptional control of gene expression. Genome Biol. 4: 223.1-223.14, 2003.  Pubmed Link

Jacobson, A. and Peltz, S.W. Destabilization of nonsense-containing transcripts in Saccharomyces cerevisiae. In: Translational Control, Second Edition (Eds: N. Sonenberg, J.W.B. Hershey and M.B. Mathews), Cold Spring Harbor Laboratory Press, N.Y., pp. 827-847, 2000.

Office: S5-117
Phone: 508-856-2442
E-mail: Allan.Jacobson@umassmed.edu
Keywords: Genetic Systems, Gene Expression

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