MassBiologics occupies two campuses in Boston, MA; one located at 305 South Street and the other located at 460 Walk Hill Street.
The South Street Campus houses Tetanus and Diphtheria vaccine (Td) bulk vaccine production in approximately 15,000 square feet of cGMP space. The cGMP manufacturing areas are supported by cGMP utilities and warehouse operations.
The South Street site includes cGMP laboratories for segregated culture, inactivation and purification of Tetanus and Diphtheria toxoids which are then aseptically formulated with aluminum phosphate to make bulk vaccine.
The Walk Hill Street Campus consists of a research and administration building and a manufacturing building. The manufacturing building houses approximately 25,000 square feet of cGMP manufacturing space with dedicated areas for aseptic fill finish and bulk drug substance production. The FDA approved filling area features a vial washing and depyrogenation tunnel meshed with a Bosch high speed filler capable of filling and capping 300 vials per minute. The packaging area is equipped with a laser printing IMA labeler, cartoner and case packer. The labeling process is monitored using state of the art camera technology. The bulk drug substance preparation area includes dedicated rooms for seed preparation, bioreactor culture and purification. Bulk cell culture is accomplished using a 55L, 500L and 2500L ABEC reactor train. The manufacturing building also houses ambient and cold warehouse storage, clean utilities, QC testing laboratories and office space. The research building houses laboratory space for product discovery and process development scientists and equipment. MassBiologics' administration, clinical and regulatory offices are also located here.