Section: Publications

Postdoctoral Position Available

Kenneth Rock, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Pathology

Other Affiliation(s):
   Center for AIDS Research
   Program in Immunology and Virology

Representative Publications:

Michalek, M.T., Grant E. Gramm, C., Goldberg, and Rock, K.L. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. 1993. Nature. 363: 552-554.

Rock, K.L., Gramm, C., Rothstein, L., Clark  , K., Stein, R., Dick, L., Hwang, D., and Goldberg, A.L. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC-class I molecules. 1994. Cell. 78: 761-771.

Kovacsovics-Bankowski, M., and Rock, K.L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. 1995. Science. 267: 243-246.

Falo, L.D., Jr., Kovacsovics-Bankowski, M., Thompson, K., and Rock, K.L. Vaccination with particulate antigen induces protective tumor immunity. 1995. Nature Medicine. 1: 649-653.

Craiu, A. Akopian, T., Goldberg, A., and Rock, K.L. Two distinct proteolytic processes in the generation of an MHC class I-presented peptide. 1997. Proc. Natl. Acad. Sci. USA. 94: 10850-10855

Sigal, LJ, Crotty, S., Andino, R., and Rock, K.L. Cytotoxic T cell immunity to virus-infected non-haematopoietic cells requires presentation of exogenous antigen. 1999. Nature. 398: 77-80.

York, I.A., Chang, S-C., Saric, T., Keys, J.A., Favreau, J.M., Goldberg, A.L. and Rock, K.L. The interferon-inducible ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming peptides to 8-9 residues. 2002 Nature Immunology, 3: 1177-1184

York, IA, Mo, AXY, Lemerise, K., Zeng, W., Shen, Y., Abraham, CR. Goldberg, A and Rock, KL. Thimet oligopeptidase can degrade antigenic peptides in the cytosol and limit MHC class I antigen presentation 2003 Immunity, 18: 429-40.

Shi, Y., Evans, JE. and Rock, KL. Molecular identification of a danger signal that alerts the immune system to dying cells. 2003 Nature, 425: 516-21

Shen, L., Sigal, LJ. Boes, M., and Rock, KL. Critical role of cathepsin S in TAP-independent MHC class I cross presentation in vivo. 2004 Immunity. 45: 218-25

Rock, KL., York  , I., and Goldberg, AL. 2004.  Post-proteasomal antigen processing for MHC class I presentation.  Nature Immunololgy. 5: 670-77

Shi, Y, Galusha, SA., and Rock KL. 2006 Elimination of an endogenous adjuvant reduces the activation of CD8 T lymphocytes to transplanted cells and in an autoimmune diabetes model. J. Immunol. Cutting Edge 176: 3905-08

York, IA, Brehm, MA, Zendzian, S., Towne, CF., and Rock, KL. 2006 ER-Aminopeptidase I (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in establishing immunodominance. Proc. Natl. Acad. Sci. USA. 103: 9202-7

Chen, C-J., Shi, Y., Hearn, A., Fitzgerald, K., Golenbock, D., Akira, S., and Rock, K.L. 2006 MyD88-dependent interleukin 1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J. Clin Invest. 116:2262-71.

Chen, C-J., Kono, H., Golenbock, D., Reed, G., Akira, S., and Rock, K.L. 2007. Identification of a key pathway required for the sterile inflammatory response triggered by necrotic dying cells. Nature Medicine. 13:851-6

Rock, KL. and Kono, H. 2008. How dying cells alert the immune system to danger. Nature Rev. Immunol. 8:279-89

Office: S2-109
Phone: 508-856-2521
E-mail: Kenneth.Rock@umassmed.edu
Keywords: Immunology, Cell Biology, Virology

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Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Rock for additional details.