Katherine Luzuriaga, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Medicine
   Pediatrics

Other Affiliation(s):
   Center for AIDS Research
   Clinical and Population Health Research
   Infectious Diseases and Immunology
   Interdisciplinary Graduate Program
   Program in Immunology and Virology
   Program in Molecular Medicine

Virus-Host Dynamics in Persistent Viral Infections

Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.

Recent Publications:

Precopio ML, Sullivan JL, Willard C, Somasundaran M, Luzuriaga K.  Differential kinetics and specificity of EBV-specific CD4+ and CD8+ T cells during primary infection. J Immunol, 170:2590-98, 2003.

Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Demostration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci USA, 101(1):239-44, 2004.

Luzuriaga K, McManus M, Mofenson L, Britto P, Graham B, Sullivan JL, the PACTG 356 Investigators. A trial of three antiretroviral regimens in HIV-1-infected children. N Engl J Med, 350(24):2471-80, 2004.

Gibson L, Piccinini G, Lilleri D, Revello MG, Wang Z, Markel S, Diamond DJ, Luzuriaga K. Human cytomegalovirus proteins pp65 and immediate early protein 1 are common targets for CD8+ T cell responses in children with congenital or postnatal human cytomegalovirus infection.  J Immunol, 172(4):2256-64, 2004.

Hochberg D, Souza T, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA.  Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting latently infected cells.  J Virol, 78(10):5194-5204, 2004.

Sanchez-Merino V, Nie S, Luzuriaga K.  HIV-1-specific CD8+ T cell responses and viral evolution in women and infants.  J Immunol, 175(10):6976-86, 2005.

Potential Rotation Projects:

Contact Dr. Luzuriaga for project details.

Assistant Professors:

Thomas Greenough, Mohan Somasundaran, Laura Gibson

Data Manager:

Margaret McManus

Research Assistants:

Frank Brewster, James Coderre, Richard Hudson, Sarah Mahoney, Sonia Trzmielina

Post-Doctoral Fellows:

Victor Sanchez-Merino

Technicians:

Bruce Blais, Robin Brody, Sheryl Dooley, Jianjun Duan, Linda Lambrecht, Erik Larson, John Latino, Joyce Pepe

Administrator:

Karen Anderson

Adminstrative Assistant:

Wanda DePasquale

Academic Background

S.B., S.M. - Massachusetts Institute of Technology

M.D. (1984) Tufts University

Professor,
Department of Pediatrics and Program in Molecular Medicine

Office: Biotech II, Suite 318
Phone: 508-856-6282
Fax: 508-856-5500
E-mail: Katherine.Luzuriaga@umassmed.edu
Keywords: Microbial Pathogenesis, T lymphocytes, Infectious Disease, HIV/AIDS, Viral Infections and Immunity

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