Section: Rotations

Postdoctoral Position Available

Ronald Iorio, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Program in Immunology and Virology

Rotation Projects

Rotation projects will involve construction of site-directed mutants or chimeras of either the attachment, fusion or V proteins and evaluation of their ability to promote the functions attributed to that protein. Depending on the target protein, the structure and function of each mutated or chimeric protein will be evaluated using several functional assays. These include flow cytometry (cell surface expression and antibody recognition), hemadsorption of red blood cells (receptor recognition activity), neuraminidase (receptor destroying activity), content mixing reporter gene assay (fusion), immunoprecipitation and SDS-PAGE (protein structure) and co-immunoprecipitation (determination of the ability of the mutated proteins to interact with a co-expressed protein). For the V protein, we will be evaluating various aspects of its interferon inhibitory activity.

Office: S5-210
Phone: 508-856-5257
Fax: 508-856-5920
E-mail: Ronald.Iorio@umassmed.edu
Keywords: Structural Biology, Biochemistry, Virology

More on Ronald Iorio's Research Research | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available A postdoctoral position is available to investigate the molecular mechanism of viral entry and fusion utilized by the attachment and fusion proteins of the paramyxoviruses, a group of negative-stranded RNA viruses which includes measles, mumps, Sendai, Newcastle disease and the parainfluenza viruses, as well as the emerging nipah and hendra viruses. The ideal candidate will be expected to have recently received a Ph.D. degree, be highly motivated and to have a strong background in virology and molecular biology.