Section: Publications

Postdoctoral Position Available

Ronald Iorio, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Program in Immunology and Virology

Representative Publications

Corey, E. A., and R. M. Iorio.  (2009).  Measles virus attachment proteins with impaired ability to bind CD46 interact more efficiently with the homologous fusion protein. Virology 383: 1-5.

Mahon, P. J., A. M. Mirza, T. A. Musich, and R. M. Iorio.  (2008).  Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: Implications for the mechanism of fusion promotion.  J. Virol. 82: 10386-10396.

Iorio, R. M., and P. J. Mahon.  (2008).  Paramyxoviruses: Different receptors - different mechanisms of fusion.  Trends in Microbiology 16: 135-137.

Corey, E. A., and R. M. Iorio (2007). Mutations in the stalk of the measles virus hemagglutinin protein decrease fusion but do not interfere with the interaction with the virus-specific interaction with the homologous fusion protein. J. Virol. 81:9900-9910.

Melanson, V.R. and R.M. Iorio. (2006). Addition of N-glycans in the stalk of the Newcastle disease virus HN protein blocks its interaction with the F protein and prevents fusion J. Virol. 80: 623-633.

Alamares, J.G., J. Li, and R.M. Iorio (2005) Monoconal antibody routinely used to identify avirulent strains of Newcastle disease virus binds to an epitope at the carboxy terminus of the hemagglutinin-neuraminidase protein and recognizes individual mesogenic and velogenic strains J. Clin. Micro 43: 4229-4233. 

Li, J., V. R. Melanson, A. M. Mirza, and R. M. Iorio.  (2005).  Decreased dependence on receptor recognition for the fusion promotion activity of L289A-mutated Newcastle disease virus fusion protein correlates with a monoclonal antibody-detected conformational change.  J. Virol. 79: 1180-1190.

Melanson, V. R., and R. M. Iorio.  (2004).  Amino acid substitutions in the F-specific domain in the stalk of the Newcastle disease virus HN protein modulate fusion and interfere with its interaction with the F protein. J. Virol. 78: 13053-13061.

Li, J., E. Quinlan, A. M. Mirza, and R. M. Iorio.  (2004).  Mutated form of the Newcastle disease virus hemagglutinin-neuraminidase interacts with the homologous fusion protein despite deficiencies in both receptor recognition and fusion promotion. J. Virol. 78: 5299-5310.

Office: S5-210
Phone: 508-856-5257
Fax: 508-856-5920
E-mail: Ronald.Iorio@umassmed.edu
Keywords: Structural Biology, Biochemistry, Virology

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Postdoctoral Position Available A postdoctoral position is available to investigate the molecular mechanism of viral entry and fusion utilized by the attachment and fusion proteins of the paramyxoviruses, a group of negative-stranded RNA viruses which includes measles, mumps, Sendai, Newcastle disease and the parainfluenza viruses, as well as the emerging nipah and hendra viruses. The ideal candidate will be expected to have recently received a Ph.D. degree, be highly motivated and to have a strong background in virology and molecular biology.