Section: Rotations

Elliot Androphy, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Dermatology
   Medicine
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Center for AIDS Research
   Clinical and Population Health Research
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Potential Rotation Projects

1. Mechanism of cutaneous and breast epithelial cell immortalization induced by the human papillomavirus E6 protein.



2. Characterization of E6 interacting proteins and their requirement for viral replication in keratinocytes.



3. Identification of cellular proteins that bind the papillomavirus E2 and their relationship to E2 functions in regulation of viral transcription, DNA regulation, and mitotic genome segregation.



4. Structure based drug design of E6 and E2 inhibitors.



5. Regulation of mRNA splicing using SMN as a model, including identification of cis acting sequences and trans-acting splicing factors.



6. Biologic screens for compounds that alter SMN slicing and may be used in therapy of Spinal Muscular Atrophy.

Office: LRB 328
Phone: 508-856-6602
E-mail: Elliot.Androphy@umassmed.edu
Keywords: Cancer Biology, Virology, Gene Expression

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