University of Massachusetts Medical School

55 Lake Avenue North
Worcester, MA 01655 

UMass Memorial Medical Center

Memorial Campus
119 Belmont Street
Worcester, MA 01605


Division of Infectious Diseases and Immunology

Research Programs

  • Treatment of HIV-infected Persons
  • Viral Immunology
  • DNA Vaccines
  • Antibacterial Host Defenses
  • Intracellular Signalling
  • Antiviral effects of Nitric Oxide
  • Cellular Growth Regulation
  • Innate immune recognition and signalling in humans and insects

Recent Publications

via PudMed

Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature. 2010 Apr 29;464(7293):1357-61.

Levitz SM. Innate recognition of fungal cell walls. PLoS Pathog. 2010 Apr 22;6(4):e1000758.

Friberg H, Burns L, Woda M, Kalayanarooj S, Endy TP, Stephens HA, Green S, Rothman AL, Mathew A. Memory CD8(+) T cells from naturally acquired primary dengue virus infection are highly cross-reactive. Immunol Cell Biol. 2010 Apr 27.

Strunk T, Power Coombs MR, Currie AJ, Richmond P, Golenbock DT, Stoler-Barak L, Gallington LC, Otto M, Burgner D, Levy O. TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremia. PLoS One. 2010 Apr 9;5(4):e10111.

He X, Mekasha S, Mavrogiorgos N, Fitzgerald KA, Lien E, Ingalls RR. Inflammation and Fibrosis during Chlamydia pneumoniae Infection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome. J Immunol. 2010 Apr 14.

Zhao H, Leu SW, Shi L, Dedaj R, Zhao G, Garg HG, Shen L, Lien E, Fitzgerald KA, Shiedlin A, Shen H, Quinn DA, Hales CA. TLR4 Is a negative regulator in noninfectious lung inflammation. J Immunol. 2010 May 1;184(9):5308-14. Epub 2010 Mar 31.

Houghton JM, Li H, Fan X, Liu Y, Liu J, Rao VP, Poutahidis T, Taylor C, Jackson E, Hewes C, Lyle S, Cerny A, Bowen G, Cerny J, Moore N, Kurt-Jones EA, Erdman S. Mutations in bone marrow derived stromal stem cells unmask latent malignancy. Stem Cells Dev. 2010 Mar 3

Brown RA, Gralewski JH, Eid AJ, Knoll BM, Finberg RW, Razonable RR. R753Q single-nucleotide polymorphism impairs toll-like receptor 2 recognition of hepatitis C virus core and nonstructural 3 proteins. Transplantation. 2010 Apr 15;89(7):811-5.