Section: Publications

Merav Socolovsky, Ph.D.,MBBS

Academic Role: Assistant Professor

Faculty Appointment(s) In:
   Cancer Biology
   Pediatrics

Other Affiliation(s):
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Selected Publications

Socolovsky, M., Dusanter-Fourt, I., Lodish, H.F.  The prolactin receptor and severly truncated erythropoietin receptors support differentiation of erythroid progenitors. J Biol. Chem. (Communication), 1997; 272:14009-14012.

Socolovsky, M., Lodish, H.F., Daley, G.Q.  Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors. Commentary, Proc. Natl. Acad. Sci., 1998; 95:6573-6575.

Socolovksy, M., Constantinescu, S., Bergelson, S., Sirtokin, A., H.F.Lodish.  S., Sirtokin, A., Lodish, H.F.  Cytokines in hematopoiesis: specificity and redundancy in receptor function.   Advances in Protein Chemistry, 1998; 52:142-199.

Socolovsky, M.,Fallon, A.E.J., Lodish, H.F. The prolactin receptor rescues EpoR -/- erythroid progenitors and replaces EpoR in a synergistic interaction with c-kit.   Blood, (Rapid Communication), 1998; 92(5):1491-1496.

Socolovsky, M., Fallon, A.E.J., Wang, S., Brugnara, C., Lodish, H.F. Fetal anemia and apoptosis of red-cell progenitors in Stat5a-/-Stat5b-/- mice: a direct role for Stat5 in  Bcl-xL - induction.   Cell, 1999; 98:181-191.

Socolovsky, M., Nam, H.-S., Fleming, M.D., Haase, V.H., Brugnara, C., Lodish, H.F.  Ineffective erythropoiesis in Stat5a-/-5b-/- mice due to decreased survival of early erythroblasts. Blood, 2001; 98:3261-3273

Brisken, C.*, Socolovsky, M.*, Lodish, H.F., Weinberg. R.A. The Signaling Domain of the Erythropoietin Receptor Rescues Prolactin Receptor-Mutant Mammary Epithelium. PNAS, 2002; 99:14241-14245*contributed equally to this work

Zhang. J., Socolovsky, M. Gross. A., Lodish., H.F.  Role of Ras signaling in erythroid differentiation of fetal liver cells: functional analysis by a flow-cytometry- based novel culture system. Blood, 2003; 102:3938-3946.

Liu, Y., Pop, R., Sadegh, C., Brugnara, C., Haase, V.H., Socolovsky, M. Suppression of Fas-FasL co-expression by erythropoietin mediates erythroblast expansion during the erythropoietic stress-response in vivo.Blood, 2006; 108:123-133

Socolovsky, M.  Molecular Insights into Erythropoietic Stress. Current Opinion in Hematology, in press.

Socolovsky, M.,Murrell, M., Liu, Y., Pop, R., Porpiglia, E., and Levchenko, A. Negative Autoregulation by Fas Mediates Robust Fetal Erytrhopoiesis . PLoS Biology, 2007; 5(10): e252.doi:10

Office: LRB 403
Phone: 508-856-3743
E-mail: Merav.Socolovsky@umassmed.edu

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