Section: Publications

Brian Lewis, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Program in Gene Function and Expression
   Program in Molecular Medicine

Other Affiliation(s):
   Graduate Program in Cancer Biology
   Interdisciplinary Graduate Program



Recent Publications

Chen, Y-W., Boyartchuk, V. and Lewis, B. C. (2009) Differential roles of insulin-like growth factor receptor- and insulin receptor-mediated signaling in the phenotypes of hepatocellular carcinoma cells. Neoplasia 11: 835-845.

Morton, J. P., Klimstra, D. S., Mongeau, M. E. and Lewis, B. C. (2008) Trp53 deletion stimulates the formation of metastatic pancreatic tumors. Am. J. Pathol. 172: 1081-1087.

Chen, Y-W., Paliwal, S., Draheim, K., Grossman, S. R. and Lewis, B. C. (2008) p19Arf inhibits the invastion of hepatocellular carcinoma cells by binding to CtBP. Cancer Res. 68: 476-482.

Paliwal, S., Kovi, R. C., Nath, B., Chen, Y-W., Lewis, B. C. and Grossman, S. R. (2007) The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res. 67: 9322-9329.

Du, Y-C., Lewis, B. C., Hanahan, D. and Varmus, H. E. (2007) Assessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.  PLoS Biol. 5: 2255-2269 (e276).

Chen, Y-W., Klimstra, D. S., Mongeau, M. E., Tatem, J. L., Boyartchuk, V. and Lewis, B. C. (2007) Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res. 67: 7589-7596.

Morton, J. P. and Lewis, B. C. (2007) Shh signaling and pancreatic cancer: implications for therapy? Cell Cycle 6: 1553-1557.

Morton, J. P., Mongeau, M. E., Klimstra, D. S., Morris, J. P., Lee, Y. C., Kawaguchi, Y., Wright, C. V., Hebrok, M., and Lewis, B. C. (2007) Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. PNAS 104: 5103-5108.

Lewis, B. C. (2006) Development of the pancreas and pancreatic cancer. Endocrinol. Metab. Clin. North Am. 35: 397-404.

Lewis, B. C., Klimstra, D. S., Socci, N. D., Xu, S., Koutcher, J. A., and Varmus, H. E. (2005) The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol. Cell Biol. 25: 1228-1237.

Lewis, B. C., Klimstra, D. S., and Varmus, H. E. (2003) The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer. Genes Dev. 17(24): 3127-3138.

Lewis, B. C., Chinnasamy, N., Morgan, R. A., and Varmus, H. E. (2001) Development of an avian leukosis-sarcoma virus subgroup A pseudotyped lentiviral vector. J. Virology 75: 9339-9344.

Fisher, G. H., Orsulic, S., Holland, E., Hively, W. P., Li, Y., Lewis, B. C., Williams, B. O., and Varmus, H. E. (1999) Development of a flexible and specific gene delivery system for production of murine tumor models. Oncogene 18: 5253-5260.

Office: LRB-521
Phone: 508-856-4325
E-mail: Brian.Lewis@umassmed.edu
Keywords: Genetic Systems, Cancer Biology, Mouse Models, Metastasis, Oncogenes/tumor suppressors

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