Section: Research

Stuart M Levitz, M.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Infectious Diseases and Immunology
   Medicine

Joint Faculty In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Interdisciplinary Graduate Program
   Program in Immunology and Virology

Interplay between a host immune system and opportunistic fungal pathogens

We are focused upon the study of the interplay between the host immune system and opportunistic fungal pathogens, particularly Cryptococcus neoformans. C. neoformans frequently infects persons with impaired T cell function, especially those with AIDS. A major ongoing project in the laboratory is the molecular characterization of cryptococcal antigens that stimulate T cells to proliferate. In this regard, we have explored the mechanisms by which mannosylation of fungal proteins contributes to antigenicity. Essential to antigenicity is efficient uptake of the fungal antigens by dendritic cell mannose receptors. The eventual goal of this project is twofold. First, to better understand how the immunocompetent host protects itself against C. neoformans. Second, to develop a recombinant vaccine that would protect individuals at risk. Using the model antigen, ovalbumin, we are also developing model recombinant vaccines that exploit the ability of fungal mannosylation to target dendritic cells. Finally, the laboratory is studying how the major virulence factor of C. neoformans, polysaccharide capsule, modifies the immunological response and
enhances the pathogenicity of the fungus.

Keywords: Pathogenesis, Vaccine

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