Section: Research

Allan Jacobson, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Interdisciplinary Graduate Program

Cytoplasmic Aspects of the Post-transcriptional Regulation of Gene Expression

Research in my laboratory is focused on the regulation of mRNA stability in the yeast Saccharomyces cerevisiae . Our efforts are currently focused on the mechanisms that dictate rapid decay of two classes of unstable mRNAs: those that are inherently unstable and those that are normally stable, but are destabilized by the presence of a premature nonsense codon. We are analyzing the function of coding sequence elements required for both types of rapid decay as well as isolating and characterizing mutants incapable of degrading either or both classes of mRNA. The latter approach has led to the identification of several trans -acting factors essential for mRNA degradation. Specific interactions of these factors are being analyzed by genetic approaches.

Office: S5-117
Phone: 508-856-2442
E-mail: Allan.Jacobson@umassmed.edu
Keywords: Genetic Systems, Gene Expression

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