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Roger Davis, Ph.D.
Academic Role: Professor
Faculty Appointment(s) In:
Program in Molecular Medicine
Joint Faculty In:
Biochemistry and Molecular Pharmacology
Other Affiliation(s):
Center for AIDS Research
Interdisciplinary Graduate Program
Program in Neuroscience
Mechanisms by which growth factors regulate cellular proliferation
 The goal of this laboratory is to understand
the molecular mechanism by which growth factors and cytokines regulate cellular proliferation
and survival. A specific focus of our studies is to understand how MAP kinase signaling
pathways, which are initiated at the cell surface, regulate the expression of genes in the
nucleus.
These MAP kinase pathways include the extracellular signal-regulated kinases (ERKs), the
c-Jun amino-terminal kinases (JNKs), and the p38 MAP kinases. The methods that we are using
include recombinant DNA technology, protein chemistry, somatic cell genetics, and general
biochemical techniques.
The significance of this research is that there are many disease states, such as cancer, that
are characterized by abnormal cellular proliferation. A detailed understanding of the
molecular processes involved in the control of cell growth is required for the design of
rational treatments for these diseases.
Office: Biotech II, Suite 309
Phone: 508-856-6054
E-mail: Roger.Davis@umassmed.edu
Keywords:
Neurobiology,
Cancer Biology,
Diabetes,
Signal Transduction
Postdoctoral Position Available
A postdoctoral position is available to study in this laboratory. Contact Dr. Davis for additional details.
An additional postdoctoral position is available immediately to study ZPR1 signaling in cell growth and development, and spinal muscular atrophy. Please send resume to Dr. Laxman Gangwani, Program in Molecular Medicine (Laxman.Gangwani@umassmed.edu).
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55 Lake Avenue North Worcester, MA 01605