Section: Publications

Victor Ambros

Academic Role: Professor

Faculty Appointment(s) In:
   Interdisciplinary Graduate Program
   Program in Molecular Medicine

Publications

Ambros V, Horvitz HR. (1984) Heterochronic mutants of the nematode Caenorhabditis elegans. Science. Oct 26;226(4673):409-16.

Ambros V. (1989)A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans. Cell. Apr 7;57(1):49-57.

Lee, R., Feinbaum, R., and Ambros, V. (1993).  The heterochronic gene lin-4 of C. elegans encodes small RNAs with antisense complementarity to lin-14.  Cell, 75, 843-854.

Moss, E., Lee, R., and Ambros, V. (1997) Control of developmental timing by the cold shock domain protein Lin-28 and its regulation by the lin-4 RNA. Cell 88, 637-646.

Olsen, P. H. and Ambros, V. (1999) The lin-4 regulatory RNA controls developmental timing in C. elegans by blocking LIN-14 protein synthesis after the initiation of translation.  Develop Biol. 216,671-680

Lee, R. C. and Ambros, V. (2001) An extensive class of small RNAs in Caenorhabditis elegans. Science 294, 862-864

Lee, R.C., Hammell C.H., Ambros V.R. (2006) Interacting endogenous and exogenous RNAi pathways in C. elegans. RNA, Apr;12(4):589-97

Gaur, A.B. , Jewell, D.A.,  Liang, Y., Ridzon, D. , Moore, J.H. Chen, C., Ambros,V. R. and Israel, M. A.  (2007). Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res 67: (6). 2456-2468.

Long, D., Lee, R., Williams, P.,  Chan, C.Y., Ambros,V. and Ding, Y. (2007). Potent Effect of Target Structure in MicroRNA Function. Nature Struct Mol Biol. 14; 287-294.

Hinas, A, Reimegård, J. Wagner, E.G.H., Nellen, W., Ambros, V.R. and Söderbom, F. (2007) The small RNA repertoire of the unicellular amoeba Dictyostelium discoideum: microRNA candidates, small antisense RNAs that may be derived from longer transcripts and multiple classes of repeat-associated RNAs. Nucleic Acids Research 2007;35(20):6714-26.

Miska, E. A., Alvarez-Saavedra, E., Abbott, A. L., Lau, N. C., Hellman, A. B., McGonagle, S. M., Bartel, D. P., Ambros, V.R. and Horvitz, H. R. (2007) Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. PLoS Genet. 2007 Dec 14;3(12):e215

Sokol, N. S., Xu, P., Jan, Y. N., and Ambros, V. (2008) Drosophila let- 7 microRNA is required for remodeling of the neuromusculature during  metamorphosis. Genes and Devel. In press

Office: Biotech II - Suite #306
Phone: (508) 856-6380
Fax: (508) 856-4289
E-mail: Victor.Ambros@umassmed.edu

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