Gastroenterology
UMassMedical School
55 Lake Avenue North
Worcester, MA 01655

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508.856.3068
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508.334.3833
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 Publications 

  1. Giel-Moloney, M., Krause, D. A., Chen, G., Van Etten, R. A., and Leiter, A. B. (2006) Ubiquitous and Uniform In Vivo Fluorescence in ROSA26-EGFP BAC Transgenic Mice. Genesis in press
  2. Schonhoff, S., Baggio, L., Ratineau, C., Ray, S. K., Lindner, J., Magnuson, M. A., Drucker, D. J., and Leiter, A. B. (2005) Energy Homeostasis and Gastrointestinal Endocrine Differentiation do not require the anorectic hormone, peptide YY. Molecular and Cellular Biology 25, 4189–4199. 
  3. Itkin-Ansari, P., Marcora, E., Geron, I., Tyrberg, B., Demeterco, C., Hao, E., Padilla, C., Ratineau, C., Leiter, A., Lee, J. E., and Levine, F. (2005) NeuroD1 in the endocrine pancreas: localization and activity as an  activator and repressor. Developmental Dynamics 233, 946-953. 
  4. Schonhoff, S., Giel-Moloney, M., and Leiter, A. B. (2004) Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. Developmental Biology 270, 443-454.
  5. Lossi, L., Bottarelli, L., Candusso, M. E., Leiter, A. B., Rindi, G., and Merighi, A. (2004) Transient expression of secretin in serotoninergic neurons of mouse brain during development. Eur J Neurosci 20, 3259-3269.
  6. Adams, S. H., Won, W. B., Schonhoff, S. E., Leiter, A. B., and Paterniti, J. R., Jr. (2004) Effects of PYY[3-36] on Short-term Food Intake in Mice are Not Affected by Prevailing Plasma Ghrelin Levels. Endocrinology 145, 4967-4975. 
  7. Schonhoff, S. E., Giel-Moloney, M., and Leiter, A. B. (2004) Development and Differentiation of Gut Endocrine Cells. Endocrinology 145, 2639-2644.
  8. Ray, S. K., Nishitani, J., Petry, M. W., Fessing, M. Y., and Leiter, A. B. (2003) Novel transcriptional potentiation of BETA2/NeuroD on the secretin gene promoter by the DNA-binding protein Finb/RREB-1. Mol Cell Biol 23, 259-271.
  9. Cotta-de-Almeida, V., Schonhoff, S., Shibata, T., Leiter, A., and Snapper, S. B. (2003) A new method for rapidly generating gene-targeting vectors by engineering BACs through homologous recombination in bacteria. Genome Res 13, 2190-2194.
  10. Ratineau, C., Petry, M. W., Mutoh, H., and Leiter, A. B. (2002) Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem 277, 8847-8853.
  11. Shih, H. H., Xiu, M., Berasi, S. P., Sampson, E. M., Leiter, A., Paulson, K. E., and Yee, A. S. (2001) HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver tissue. Mol Cell Biol 21, 5723-5732. 
  12. Ratineau, C., Ronco, A., and Leiter, A. B. (2000) Role of the amino-terminal domain of simian virus 40 early region in inducing tumors in secretin-expressing cells in transgenic mice. Gastroenterology 119, 1305-1311. 
  13. Rindi, G., Ratineau, C., Ronco, A., Candusso, M. E., Tsai, M., and Leiter, A. B. (1999) Targeted ablation of secretin-producing cells in transgenic mice reveals a common differentiation pathway with multiple enteroendocrine cell lineages in the small intestine. Development 126, 4149-4156.
  14. Mutoh, H., Naya, F. J., Tsai, M. J., and Leiter, A. B. (1998) The basic helix-loop-helix protein BETA2 interacts with p300 to coordinate differentiation of secretin-expressing enteroendocrine cells. Genes Dev 12, 820-830.
  15. Mutoh, H., Fung, B. P., Naya, F. J., Tsai, M. J., Nishitani, J., and Leiter, A. B. (1997) The basic helix-loop-helix transcription factor BETA2/NeuroD is expressed in mammalian enteroendocrine cells and activates secretin gene expression. Proc Natl Acad Sci U S A 94, 3560-3564.
  16. Naya, F. J., Huang, H. P., Qiu, Y., Mutoh, H., DeMayo, F. J., Leiter, A. B., and Tsai, M. J. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev 11, 2323-2334. 

Andy Leiter

Andrew Leiter, MD PhD

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