Section: Rotations

Richard Fenton, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Physiology

Potential Rotation Projects

Project #1:

AMP-sensitive cytosolic 5'-nucleotidase activity elicits the metabolism of AMP to adenosine in the cardiomyocyte. The subsequent transport of adenosine to the extracellular compartment occurs via a diffusion-mediated transport. One mechanism by which extracellular adenosine levels can be elevated with aging is via enhanced activity of this enzyme. The rotation would consist of literature-based assay development with application using heart samples obtained from aged and young adult rats to determine if the enzyme activity is altered with aging.

Project #2:

Analysis of enzyme activities "on the bench" may not reveal differences which are expressed only in the intact cell. Studies will include the perfusion of intact hearts with radioactive substrates and the isolation of cellular metabolites with high performance liquid chromatography. The goal is to determine how aging modifies cellular purine metabolism with particular reference to IMP, AMP, inosine and adenosine.

Office: S4-147
Phone: 508-856-6618
Fax: 508-856-5997
E-mail: Richard.Fenton@umassmed.edu
Keywords: Physiology, Signal Transduction

More on Richard Fenton's Research Research | Publications | Rotations | Biography View All Sections on One Page