Postdoctoral Position Available
Two Post Doctoral Positions are currently available
Calcium Signaling
Objective: To study the extent and mechanisms of intercellular calcium waves that propagate between different cell types that are in close contact in the in tact tissue. The primary focus will be on communication between airway epithelial cells and air smooth muscle cells to determine if such processes are relevant to airway hyper-responsitivity or inflammation associated with asthma and cystic fibrosis. Other biological interfaces of interest would be the blood-brain barrier.
Recent Papers:
Leybaert et al., (1998) Glia, 24, 398-407.
Strahonja and Sanderson, (2000) Glia, 28, 97 - 113.
Paemeleire et al., (2000) Mol. Biol. Cell. May 1st Issue
This work will involve primary tissue culture studies of cells from rabbit and mice airways, glial cells or cell lines. In addition, the exploration of transgenic or knockout mice tissues will be emphasized.
The major techniques to be used will be video fluorescence imaging, flash photolysis, electrophysiology and tissue culture. A confocal microscopy is currently being developed for these studies.
Ideally, applicants should have some experience with the above techniques as well as additional experience with computers, networking and programming (in C++, Windows 98). Molecular biology skills sufficient for the application of constructs as imaging tools would also be very useful.
This work has been recently funded by NIH and the position will be available for 2 years following a probationary period. Salary will be in accordance with NIH guide lines and will reflect years of post-doctoral experience.
Ciliary Regulation
Objective: To study the mechanisms by which calcium and ATP regulate ciliary beat frequency and or epithelial function. These studies are relevant to epithelial function in airway disease such as cystic fibrosis.
Recent Papers:
Lansley and Sanderson (1999) Biophysical J. 77, 629-638.
Evans and Sanderson (1999) Am. J. Physiol 277, (Lung Cell. Mol. Physiol. 21) L30-L41.
Evans and Sanderson (1999) Cell Calcium 26, 103-110.
This work will involve primary tissue culture studies of cells from rabbit and mice airways. In addition, the exploration of transgenic or knockout mice tissues will be emphasized.
The major techniques to be used are high speed-phase contrast imaging, video-speed fluorescence imaging, flash photolysis, and tissue culture.
Ideally, applicants should have some experience with the above techniques as well as additional experience with computers, networking and programming (in C++, Windows 98). Molecular biology skills sufficient for the application of constructs as imaging tools would also be very useful.
This work has been recently funded and the position will be available for 2 years following a probationary period. Salary will be in accordance with NIH guide lines and will reflect years of post-doctoral experience.
Please Send CV to:
Dr. Michael J. Sanderson
Department of Physiology
University of Massachusetts Medical School
55 Lake Avenue North
Worcester, MA 01655
Please also indicate in your application:
- the position applied for (there are two)
- your particular knowledge and enthusiasm regarding the topic and interest in this project - this is very important
- your salary requirements
- your availability
- your email address (for acknowledgements of applications)
- three names for letters of recommendations
An electronic submission is possible but it must be submitted as an attached formatted document in WORD
For addition questions and information mailto:michael.sanderson@umassmed.edu
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55 Lake Avenue North Worcester, MA 01655