Section: Rotations

Donald Tipper, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Molecular Genetics and Microbiology

Other Affiliation(s):
   Bacterial Genetics and Pathogenesis
   Interdisciplinary Graduate Program

Rotation Projects

1. Determine the mechanism of PrP^Ctm production by constructing PrP mutants with N-terminal glycosylation sites and analyzing their modification in yeast and in vitro.



2. Test the role of PrP^Ctm in prion pathology by determining the effects of changing the charged topogenic signals in PrP on transmembrane insertion and pathogenicity.



3. Isolate new pio mutants and determine their effects on normal yeast TM proteins.

Office: S6-228
Phone: 508-856-2308
E-mail: Donald.Tipper@umassmed.edu
Keywords: Intracellular Trafficking, Cell Biology, Microbial Pathogenesis

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