Section: Rotations

Postdoctoral Position Available

Lucio Castilla, Ph.D.

Academic Role: Associate Professor

Faculty Appointment(s) In:
   Program in Gene Function and Expression
   Program in Molecular Medicine

Other Affiliation(s):
   Center for AIDS Research
   Graduate Program in Cancer Biology
   Interdisciplinary Graduate Program

Potential Rotation Projects

Project 1: On the study of the role of CBF factor in hematopoiesis and leukemia, you will use knock-in and knock-out mice for each CBF protein to study their effects in stem cell function.

Project 2: We have used Affymetrix oligonucleotide arrays to identify gene expression profile of various hematopoietic progenitors expressing Cbfb-MYH11. You will use molecular biology techniques to validate and characterize their function during differentiation.

Project 3: We have used retroviral insertional mutagenesis to identify candidate genes that may collaborate with Cbfb-MYH11 in leukemia. You will use this approach to identify and study new Cbfb-MYH11 cooperating oncogenes.

Project 4:  We use molecular and genetic tools to study the mechanism of PlagL2 function in hematopoiesis. We have identified candidate PlagL2 targets using Affymetrix-based gene expression profiling. You will participate in the characterization of these targets.

Office: LRB 622
Phone: 508-856-3281
E-mail: Lucio.Castilla@umassmed.edu
Keywords: Hematopoiesis, Cancer Biology, Stem Cell Biology, Mouse Genetics, Gene Regulation

More on Lucio Castilla's Research Research | Publications | Rotations | Personnel | Biography View All Sections on One Page

Postdoctoral Position Available A postdoctoral position is available to study in this laboratory. Contact Dr. Castilla for additional details.