LRB 

Research at UMMS has already led to exciting advances in the treatment of disease and injuries, and the future promises many more health care delivery breakthroughs. And while patient application is the ultimate goal of UMMS research, economic spinoff to the surrounding region is a significant and important byproduct. 

Research

Current Topics

  • Genetic control of autoimmune diabetes in animal models, including Lentivirus mediated gene delivery for transgenesis and gene silencing
  • Development of ‘humanized’ mice (immunocompromised mice with a human immune system) for studies of type 1 diabetes and islet transplantation
  • Development of novel technology for non-invasive glucose measurement
  • Markers of thyroid cancer activity
  • Clinical trials for new agents in diabetes management
  • Gene silencing as therapy for medical disorders and atherosclerosis
  • Neuronal cell signaling
  • Genetics of pheochromocytoma
  • Mechanisms of circadian rhythmicity
  • Clinical effects of growth hormone therapy in adults
  • Molecular mechanisms in Huntington’s disease pathogenesis
  • Molecular mechanisms of axonal growth and synaptogenesis
  • Role of viruses in transplantation tolerance induction and the pathogenesis of autoimmune diabetes
  • Role of ER stress pathways in diabetes pathogenesis and lymphocyte activation
  • Role of pericentrin in beta cell function
  • Molecular biology of islet cell development in zebrafish 

Past Topics

  • Signaling and trafficking in insulin resistance
  • MicroRNA regulation of smooth muscle cell growth and apoptosis
  • Vorinostat (SAHA) in bone metastases of prostate cancer
  • Growth and differentiation potential of human embryonic stem cells
  • Improvement of glycemic control in Latino patients with Type 2 diabetes
  • Genetic screening for the susceptibility of glucose intolerance in obese human subjects
  • Biological role of the family of JNK kinases
  • Role of various estrogren receptor beta (ERβ) isoforms in breast cancer
  • Studying the relationship between the timeless gene and melatonin receptors in the pars tuberalis of mouse.
  • Transforming growth factor alpha in the suprachiasmatic nucleus of a diurnal rodent
  • Exploring the role of Toll like receptors in autoimmune diabetes
  • Intracellular membrane trafficking

 

Endocrinology & Metabolism
UMass Medical School
55 Lake Ave North
Worcester MA 01655
508-856-3536