Funded Active Studies

Steven B. Bird, MD (Principal Investigator)
Romolo Gaspari, MD (Co-Investigator)
National Institute of Neurological Disorders and Stroke (NINDS)
Pharmacotherapy to counterACT Parathion-induced NMJ dysfunction.
The proposed research promises to improve public health by mitigating the acute and subacute toxic effects of OP pesticides after intentional or accidental poisoning.

Edwin D. Boudreaux, PhD
National Institute of Mental Health (NIMH)
Emergency Department Patient Safety and Follow-up Evaluation ED-SAFE 2: Translating Safety Planning into Practice
The ED-SAFE-2 will study both the sustainability of successfully implemented universal suicide risk screening and implementation of a brief suicide intervention, the Safety Planning Intervention, into routine care in eight EDs using Lean performance improvement strategies

National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Remote Brief Intervention and Referral to Treatment Service for Alcohol (R-BIRT)
The Remote Brief Intervention and Referral to Treatment Service for Alcohol (R-BIRT) is an innovative telehealth service model with potential to improve public health through evidence based counseling for patients who exceed the NIAAA low risk drinking limits or have evidence of an Alcohol Use Disorder with professional and self-helped treatment. Our aims are following (1) Conduct a randomized controlled trial (RCT) testing the non-inferiority of R-BIRT compared to best practice , in-person SBIRT for improving alcohol related outcomes. (2) Conduct economic analyses testing R-BIRT against in-person SBIRT. (3) Test exploratory models of alcohol use after receiving an intervention in the ED.

MA Infrastructure Capacity Building
Integrating Medical and Behavioral Health Services in the Emergency Department
This project will enhance the technology and information service infrastructure needed to fully integrate behavioral health (BH) services into the ED. It will deploy computerized systems that can identify BH issues, facilitate both computer and interventionist-delivered BH services, and build a data-mart that will support measurement and tracking of a range of patient outcomes.

UMass Center for Clinical and Translational Science Conference Grant
UMMHC-UMMS Zero Suicide Capacity Building
UMMHC and UMMS have formed a collaborative effort aimed at building a systems-based approach to suicide prevention referred to as the System of Safety (SOS) and which is patterned on the Zero Suicide model. This conference funding helped to plan and promotes the SOS efforts through bringing together diverse stakeholders who are geographically dispersed and who have heretofore only collaborated in “virtual space.”

American Foundation for Suicide Prevention (AFSP)/University of Pennsylvania (UPENN)
Safety Planning Intervention to Reduce Short Term Risk
To test the efficacy of the Safety Planning Intervention to reduce suicidal behaviors using a randomized controlled trial design comparing two groups: Intervention (Safety Planning Intervention) vs Treatment as usual.

MyLink Evaluation Project
Identify the patient population that utilizes ED for non-emergent complaints.  Produce baseline analyses as well as quarterly and cumulative reports that track progress, both overall and specifically for individuals whose care is paid for by the Commonwealth.  Define and design an intervention to reduce non-emergent ED use.

Psychiatric Emergency Research Collaboration (PERC-05)
Universal Suicide Screener aimed to validate a newly developed Computer Adapted Test and other measures against the gold standard of suicide screeners, the Columbia Suicide Severity Risk Scale (CSSRS).

Integrated Emergency Medicine (IEM) Health Survey
Implementation of a universal health survey pertaining to medical and behavioral health issues administered to patients in the University ED. Tablets will be installed in the rooms and waiting area for patients to take the survey as they come in. The survey comes in English, Spanish, and Portuguese.

Edward Boyer, MD
National Institute on Drug Abuse (NIDA)
Mentoring in Advanced mHealth Interventions for Drug Abuse and HAART Adherence
Supports the training and launching of careers of a strong cadre of rigorously trained new patient oriented drug abuse investigators dedicated to using novel approaches to expand knowledge and develop new avenues for clinical applications of mobile health (mHealth) technologies to promote abstinence, prevent relapse, and support adherence to antiretroviral medications in HIV+ persons.

John Broach, MD
Homeland Security Central Massachusetts Regional Planning Commission and the City of Worcester Emergency Management
Disaster Lab/Central Shield 2016
Full scale disaster response exercise involving members of the city of Worcester and surrounding towns first response and emergency management agencies as well as Worcester hospitals.

Jennifer Carey, MD
UMass Faculty Scholars Award
Identifying the Role of Social Media in Adolescent Suicide and Self-Harm Attempts

Stephanie Carreiro, MD
National Institutes of Health (NIH), Clinical Research Scholar Award
iSense: Wearable Biosensors to Evaluate the Evolution of Opioid Tolerance
Utilization of mobile biosensors to evaluate the evolution of opioid tolerance.

UMass Faculty Scholars Award
Wearable biosensors for the detection of recurrent opioid toxicity after reversal.
Utilization of mobile biosensors to detect recurrent opioid toxicity in emergency department patients that have received the opioid antagonist naloxone.

Peter Chai, MD
American College of Medical Toxicology (ACMT) Medical Toxicology Foundation
Naloxone Distribution Patterns in Patients with a History of Heroin Abuse

Chad Darling, MD
National Institutes of Health (NIH)
SCREENED-ED: Delirium Screening of the Elderly in the Emergency Department

U.S. Department of Defense
HEROS: Hemodynamic Evaluation of Resuscitation with Oximeter Sensors
DOD sponsored study to test the ability of wearable, pulse oximeter based sensors to detect hemorrhage in trauma patients and body volume depletion in dehydrated patients.

Radiometer Medical
Radiometer sponsored study testing the viability, efficiency, and efficacy of a Point of Care (POC) troponin testing device.

Romolo Gaspari, MD
UMass Carl Akins Grant
Automated Ultrasound Image Transfer
The goal of this project is to develop software that will move ultrasound images into PACS system in a way to retain peer review protection.

Marc Gautreau, MD
UMass Clinical
Effect of frequent small scale disaster drills on ED performance in actual emergency management situations and full scale drills.  Ongoing study analyzing the effectiveness of multiple “micro-drills” in standardizing staff behavior throughout the institution in managing various phases of an internal or external disaster.

John P. Haran, MD
National Institute of Allergy and Infectious Diseases (NIAID)
Gut Microbiome modeling to predict Clostridium difficile infection in hospitalized patients.
This exploratory grant will use mathematical modeling based off of a hospitalized patient’s microbiome at the start of antibiotic therapy to predict which patients will go on to develop Clostridium difficile infection.

Society of Academic Emergency Medicine (SAEM)
Cytokine Responses in Patients Presenting with an Acute Respiratory Illness
To study a panel of cytokine and acute phase reactants in patients presenting to the Emergency Department with an acute respiratory illness that will be able to discriminate between bacterial and viral infections while predicting severity and outcomes in bacterial pneumonia infection.

Hillary Irons, MD
Peter Hackett-Paul Auerbach Young Investigator Grant; Wilderness Medical Society
Altitude Illness
Acute mountain sickness is common and early detection is crucial to prevent deterioration, however few field assessments objectively measure signs and symptoms. There is a significant need for an objective, quantitative tool to measure cognitive and physical impairment related to altitude illness. Furthermore, there is a need for this assessment tool to be portable and able to be administered quickly which can be used in the field to guide symptom management and evacuation decisions. Traumatic brain injuries manifest many of the same physical and cognitive deficits as altitude illness. We propose to adapt and test modified versions of sideline concussion assessment tools to be administered rapidly on a portable device to provide immediate, objective feedback on symptoms and neurocognitive deficits in AMS. We hypothesize that the modified assessment tools can be used to quantify AMS signs and symptoms as well as manifesting physical and cognitive deficits.

Jonathan E. Slutzman, MD
Time Driven Activity Based Costing (TDABC) of Emergency Care (unfunded)
Estimate the true marginal costs of care provided for a subset of emergency medical presentations, starting with opioid overdose, using TDABC techniques.

Environmental impacts of Health Care (unfunded)
Estimate the environmental life cycle impacts of care processes, starting with disposable versus reusable laceration repair kits and plaster versus fiberglass splinting materials in emergency departments.  Additionally, estimate the life cycle financial costs to the hospital for each option.

Most Expensive Diagnoses in Emergency Medicine (unfunded)
Determining the most expensive conditions treated in emergency departments in the United States and estimating total costs of emergency medical care, including developing novel methods of estimating costs from charges in the Nationwide Emergency Department Sample (NEDS) and proposing multiple methods for accounting emergency department costs.

Joseph Tennyson, MD
Olympus America
A comparison of early deployment of a video capsule (Endocapsule EC-10) in the Emergency Department versus conventional work-up of non-hematemesis gastrointestinal bleeding with late capsule endoscopy.

Retrospective Analysis of an EMS Physician Medical Control Database (unfunded)
Our EMS Physicians provide a Medical Control System for all affiliated EMS Services.  We are conducting a descriptive review of the nature of calls made to the Medical Control Number and the degree to which outcomes were alterd by the process.

Cost-Benefit Analysis of Helicopter EMS vs. Ground Critical Care (unfunded)
We are reviewing outcomes and estimated costs of patients who underwent transport by helicopter or by the same critical care crew configuration in a ground vehicle.

Apneic Oxygenation in Prehospital Rapid Sequence Intubation (unfunded)
This project will evaluate the frequency of hypoxic episodes during Prehospital Rapid Sequence Intubation using a nasal cannula for passive delivery of oxygen during the procedure.

Retrospective Analysis of Injury Patterns at Concert Venues with Mosh Pits (unfunded)
Patient presentation rates for rock concerts are published and well establish.  We are reviewing the presentation rates and injury patterns at concerts with defined “Mosh Pits”.  This is based on retrospective review of cases presenting to the first-aid tent at eight events over a four year period.

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