Name | Research |
Victor Ambros, PhD
Molecular Medicine | Identification of microRNAs circulating in human blood plasma as potential biomarkers for diabetes |
Neil Aronin, MD*
Medicine/Endocrinology | Apoptosis, cell signaling, genetic disease |
Ingolf Bach, PhD*
Gene Func. & Exp. | The regulation of LIM home domain (LIM-HD) proteins by cofactors mainly during nervous system development |
Eric Baehrecke, PhD
Cancer Biology | Insulin, PI3K, and TOR signaling, steroid signaling autophagy, nutrient utilization and bioenergetics, cell survival and death |
Leslie Berg, PhD
Pathology | Immune tolerance and autoimmunity, lymphocyte activation, signal transduction |
Rita Bortell, PhD*
Medicine/Diabetes | The role of gut immunity in the pathogenesis of autoimmune diabetes using the BB rat as a model |
Vivian Budnik, PhD
Neurobiology | Investigate the role of insulin within the nervous system |
Anthony Carruthers, PhD*
Biochem & Mol Biology | Sugar transport |
Lucio Castilla, PhD
Gene Func. & Exp. | Identifying genes altered in diabetes progression |
Francis Ka-Ming Chan, PhD
Pathology | TNF and TNF receptor mechanism in regulating immune and autoimmune systems in diabetes and lupus |
Silvia Corvera, MD*
Molecular Medicine | Insulin action, membrane trafficking glucose transporters, exocytosis |
Roger Craig, PhD
Cell Biology | Myosin molecules, thick filaments and the actin-myosin complex |
Michael Czech, PhD*
Molecular Medicine | Insulin action, glucose transport |
Roger Davis, PhD*
Molecular Medicine | Study of the role of MAP kinases in insulin action and insulin secretion |
Paul Dobner, PhD*
Mol. Genetics & Microbiology | Neurotensin, fat, metabolism, hormones |
Stephen Doxsey, PhD
Molecular Medicine | Autoimmunity, autoantibodies, vascular damage, sclerosis |
Patrick Emery, PhD
Neurobiology | How the circadian photoreceptor CRYPTOCHROME transmits light information to the circadian pacemaker |
Robert Finberg, MD
Medicine | Coxsackie and Adenovirus receptors (CAR) characterized by defining the expression of the CAR protein in the pancreas, viral pathogenesis of diabetes |
Terence Flotte, MD*
Dean, Medical School | Immunologic aberrations in cysyic fibrosis (CF) leading to CF-related diabetes and other hyperinflammatory complications |
Kevin Fogarty, MS*
Physiology | Biomedical Cell Imaging |
Guangping Gao, PhD*
Gene Therapy | Molecular pathogenesis and gene therapy of type II diabetes. This will be accomplished by combining unique tissue tropism of AAV serotype vectors with tissue specific, pharmacologically and micro RNA regulated gene expression cassettes for either beta-cell ablation and/or gene transfer |
Rachel Gerstein, PhD
Mol. Genetics & Microbiology | V(D)J recombination, autoimmunity, immune tolerance |
Michael Green, MD, PhD
Molecular Medicine | Gene expression, RNA splicing, transcription factors |
Dale Greiner, PhD*
Medicine/Diabetes | Animal models of diabetes, thymic differentiation, autoimmunity |
Olga Hardy, MD*
Pediatrics | The role of adipose inflammation in the pathogenesis of obesity-related comorbidities in adolescents |
Eric Huseby, PhD*
Pathology | T cell tolerance and autoimmunity to tissue specific antigens |
Mitsuo Ikebe, PhD
Physiology | Mechanism of insulin in vascular smooth muscle contraction |
Anthony Imbalzano, PhD*
Mol. Genetics & Microbiology | Role of hSWI/SNF Chromatin Remodeling Enzymes in Adipocyte Signaling and Differentiation |
Tony Ip, PhD*
Molecular Medicine | MAP kinase signaling, immune response |
Allan Jacobson, PhD*
Mol. Genetics & Microbiology | Regulation of mRNA stability and translation |
Stephen Jones, PhD
Cell Biology | Transgenic mice, knockout mice, mouse models, cancer |
Joonsoo Kang, PhD*
Pathology | Impact of spatially and temporally regulated CTLA-4 expression in T cells on the pathogenesis of autoimmune diabetes |
Paul Kaufman, PhD
Gene Func. & Exp. | Molecular mechanisms of histone deacetylase-regulated pancreatic cell development and gene expression. Development of recombinant viral tools for overexpression and knockdown of gene expression |
Shalesh Kaushal, MD, PhD*
Ophthalmology | Small molecule therapeutics for diabetes utilizing the streptozotocin and NOD mouse models. |
John Keaney, MD
Cardiology | Mitochondria, endothelial function, redox-sensitive signal transduction |
Michelle Kelliher, PhD
Cancer Biology | TNF signaling related to anti-apoptotic pathways, TNF induced insulin resistance |
Norman Kennedy, PhD*
Molecular Medicine | Mechanisms of Insulin Resistance |
Catarina Kiefe, MD, PhD*
Quantitative Health Sciences | |
Daniel Kilpatrick, PhD
Physiology | Transcriptional Control of Cellular Differentiation |
Jason Kim, PhD*
Molecular Medicine | Obesity, insulin resistance and type 2 diabetes. Role of inflammation in diabetes and cardiovascular complications. Metabolic phenotying of transgenic mouse models of obesity, diabetes and its complications |
Hardy Kornfeld, MD*
Pulmonary | Identification of specific deficits in innate and adaptive immunity in TB caused by hyperglycemia (and hyperlipidemia) |
Timothy Kowalik, PhD
Mol. Genetics & Microbiology | Apoptosis, proliferation, RNAi applications in islet transplantation |
Evelyn Kurt-Jones, PhD
Medicine | Explore ways to prevent or control innate receptor triggered inflammation and the development of autoreactive T cell responses the initiate and sustain diabetes pathogenesis. |
David Lambright, PhD*
Molecular Medicine | Membrane trafficking, G proteins, phosphoinositide signaling |
Lucia Languino, PhD
Cancer Biology | Role of cell surface receptors, Integrins in cell proliferation |
Nathan Lawson, PhD*
Gene Func. & Exp. | Work to dissect the signals that are required for proper pancreas development and function |
Mary Lee, MD*
Pediatrics | Investigation of the psychosocial issues related to the management of diabetes in children |
Andrew Leiter, MD, PhD
Medicine/Gastroenterology | Role of enteroinsular axis in glucose metabolism; differentiation of pancreatic and gut endocrine cells |
John Leszyk, PhD*
Biochem. & Mol. Pharm. | Protein microanalysis |
Brian Lewis, PhD
Gene Func. & Exp. | Correlation between diabetes and pancreatic cancer |
Jane Lian, PhD
Cell Biology | Bone, glucocorticoid, vitamin D, gene therapy |
Egil Lien, PhD
Medicine/Infectious Disease | Toll-like receptors (TLRs) in the onset of viral autoimmune diabetes mellitus triggered by the innate immune system. |
Shan Lu, MD, PhD
Medicine | Immunogenic role of Coxsackie virus, DNA vaccines |
Yungsheng Ma, MD, PhD*
Prev. & Behav. Medicine | Diet intervention to improve glycemic control in diabetes |
Junhao Mao, PhD
Cancer Biology | Investigate the role of Hh and BMP signaling in diabetes and pancreatic cancer progress. |
Craig Mello, PhD
Molecular Medicine | Tyrosine kinase signaling and the role ofGSK-3 in development, RNA interference as a tool for targeted gene inactivation. |
Arthur Mercurio, PhD
Cancer Biology
| Role of insulin signaling and insulin receptor substrate proteins in regulating aerobic glycolysis in breast tumor cells |
John Mordes, MD*
Medicine/Endocrinology | Type 1 diabetes genetics and immunology |
Paul Odgren, PhD
Cell Biology | Hyperparathyroidism in skeleton and marrow maintenance; endocrine and paracrine effects of PTH, vitamin D, IGF’s. |
Sherry Pagoto, PhD*
Prev. & Behav. Medicine | Psychiatric co-morbidities of obesity and type 2 diabetes; role of stress in development of insulin resistance |
Gregory Pazour, PhD*
Molecular Medicine | Function of primary cilia on beta cells in pancreatic islets |
Oliver Rando, MD,PhD
Biochem. & Mol. Pharm. | Transgenerational control of metabolic state by diet in mice |
Joel Richter, PhD*
Molecular Medicine | The role of CPEB-mediated translational control in insulin-signaling and diabetes. |
Kenneth Rock, MD*
Pathology | T cell activation, MHC molecules, mechanisms of antigen presentation that contribute to immunity/autoimmunity, immune tolerance to treat autoimmunity and support islet cell transplantation. |
Milagros Rosal, PhD*
Prev. & Behav. Medicine | Diabetes self-management interventions adherence to dietary and physical activity interventions among low-income Hispanics with type 2 diabetes. Psychosocial factors in diabetes self-management. Diabetes and depression. Diabetes prevention interventions |
Alan Rothman, MD
Ctr for ID & Vac Research | Humanized mouse models of transplantation and immunity |
Charles Sagerstrom, PhD*
Biochem. & Mol. Pharm. | Analysis of Islet development In Zebrafish |
David Serreze, PhD*
Jackson Lab | Autoimmunity, immune tolerance, immunogenetics |
Leonard Shultz, PhD*
Jackson Lab | Animal models, developmental immunobiology, immunodeficiency, autoimmunity |
Hayla Sluss, PhD
Medicine/Endocrinology | p53 connection to obesity in fat physiology, pathology and role in diabetes |
Merav Socolovsky, MD, PhD
Pediatrics | Molecular mechanisms of stress erythropoiesis related to anemia and renal disease in diabetes |
Babs Soller, PhD
Anesthesiology | Develop and demonstrate spectroscopic-based measurement techniques to identify both large and small vessel vascular impairment in the lower extremities |
Jie Song, PhD*
Orthopedics | Novel synthetic scaffolds for localized and sustained delivery of exogenous growth factors expediting the repair of diabetic bony lesions |
Gary Stein, PhD
Cell Biology | Molecular studies integrating hormone responses with bone tissue-specific gene expression |
Lawrence Stern, PhD*
Pathology | Biochemical and cellular studies in molecular events that lead to T cell activation and tolerance |
Juerg Straubhaar, PhD*
Molecular Medicine | Bioinformatics Core Director |
Gyongyi Szabo, MD, PhD
Medicine | NASH - non-alcoholic, steato-hepatitis glucocorticoid response element |
Heidi Tissenbaum, PhD*
Molecular Medicine | Genetic and molecular analysis of new genes in the insulin-like signaling pathway in C. elegans. |
Kimberly Tremblay, PhD
Vet & Animal Scien. | Understanding the molecular and morphological mechanisms underlying the formation of the pancreas from the endoderm. |
Fumihiko Urano, MD, PhD*
Gene Func. & Exp. | PI 3-kinase and its targets in insulin-responsive cells |
Scott Waddell, PhD
Neurobiology | Understanding the intersection between food-related memory and the motivation to use it |
Marion Walhout, PhD*
Neurobiology | Fat storage problems in obesity and lipodystrophy in the development of type 2 diabetes |
Yong-Xu Wang, PhD*
Gene Func. & Exp. | Transcriptional control of fatty acid and glucose metabolism and its implications in obesity and diabetes |
David Weaver, PhD
Neurobiology | Circadian rhythms in endocrine function, the mechanisms of hormone action, and related endocrine disorders |
Raymond Welsh, PhD*
Pathology | Viral immunology, transplantation, cytotoxic T cells, NK cells, autoimmunity |
George Witman, PhD*
Cell Biology | Cellular motility, microtubules |
Bruce Woda, MD*
Pathology | Transplantation immunology, immune tolerance, type1 diabetes |
Robert Woodland, PhD
Mol. Genetics & Microbiology | Gene transfer using replication incompetent adenovirus vectors. Potentiation of tolerance induction regimens by the transfer of cytokine genes. |
Zoushang Xu, PhD
Biochem. & Mol. Pharm. | Generation of rat models using transgenic RNAi technology |
Phillip Zamore, PhD
Biochem. & Mol. Pharm. | Fundamental mechanisms of mRNA silencing, RNA interference, miRNA mediated silencing |
| * = Primary Members | |