Courses in Immunology & Virology
BBS 755 Infection and Immune Response
BBS 833 Graduate Student Seminar in Immunology & Microbiology
BBS 821 Molecular & Cellular Immunology
BBS 834 Immunobiology & Microbiology Seminar & Discussion
BBS 822 Advanced Animal Virology
BBS 846 Immunology/Microbiology Tutorial
BBS 823 Advanced Bacterial Pathogenesis
MS 850 Laboratory Rotation in Immunology & Microbiology
BBS 832a Introduction to Flow & Image Cytometry
MS 860 Qualify Examination
BBS 832b Introduction to Flow & Image Cytometry
900 Thesis Research in Immunology or Virology or Bacteriology
1. BBS 755 Infection and Immune Response
Infectious disease is among the strongest agents of natural selection, and adaptations constituting the armament of pathogens and the defense of the host involve many of the most fascinating mechanisms in biology. This course presents a modern view of the basic principles of immunology, bacterial pathogenesis, and virology, providing background for advanced course work in microbiology, microbial pathogenesis and immunology. We will focus on three themes; (1) basic properties of microbes and, the mammalian host defenses that have evolved to respond to them, (2) the interplay - in both dynamic and evolutionary sense - between host defenses and microbial virulence, and (3) the mechanisms of pathogenesis during infection. Comparative clinical and epidemiological pictures of selected diseases will be presented, and will serve as a framework for development of key molecular, cellular, and physiological concepts. Students taking this course will be eligible to continue advanced studies in the Immunology and Microbiology program. Spring. L. Stern 3 credits. Prerequisites: Core Course Blocks I and II.
2. BBS 821 Molecular & Cellular Immunology
Recent conceptual advances in both molecular and cellular immunology are explored through the reading and discussion of research papers. Students further develop the ability to formulate hypotheses and design experiments through writing a research proposal. Topics covered include innate immunity, development of T cell and B cells, immune responses to infections, and new approaches to development of vaccines. Prerequisites: Core Course and BBS 755.
3. BBS 822 Advanced Animal Virology
This is a paper reading-based course discussing in depth new findings in animal virology, including viral biochemistry and molecular biology, genetics, oncogenesis, and pathogenesis. The course will be team-taught by UMMS faculty. The course will begin with introductory lectures to provide background for more advanced readings. Students will then cover different specific areas chosen by the professors in detail with paper readings. At the end of the course the students will write a research proposal and present it to the class and faculty. R. Welsh. Fall. 3 credits. Prerequisite: Core Course and BBS 755.
4. BBS 823 Advanced Bacterial Pathogenesis
Spanning the eukaryotic and prokaryotic worlds and involving an array of disciplines -- from genetics, cell biology, and immunology, through epidemiology and evolutionary biology -- bacterial pathogenesis is a fascinating and dynamic area of study. In particular, exploring the intricate mechanisms that pathogenic bacteria have evolved for manipulating mammalian systems at the cellular and molecular levels is contributing much to our knowledge of cell biology and immune system function. Advances in microbial genomics and genomic level genetic approaches, coupled with excellent small animal infection models and sophisticated mouse genetics, hold the promise of continued rapid progress. This course, grounded in current literature, will introduce students to selected topics at the forefront of research in bacterial pathogenesis. Specific topics to be investigated will be based on interests of the class. Students will present reviews of selected research articles and develop and present brief research proposals addressing issues related to the articles under review. In addition to introducing the modern literature and experimental approaches to bacterial pathogenesis research, the format of this course is intended to assist students with preparation for qualifying examinations. The participating faculty will introduce topics, provide background information, and meet individually with students to provide constructive criticism of In-class presentations. The majority of class time will be devoted to open discussion. J.Goguen Fall. 2 credits. Prerequisites: Core Course, BBS 755 or special permission from the instructor.
5. BBS 832a Introduction to Flow & Image Cytometry
This course serves as an introduction to the technical aspects of Flow and Image Cytometry. It is a hands on, lab-based program emphasizing on Flow and Image Cytometry instrumentation, components, cell sample staining procedures for immunophenotyping, DNA analysis and Image analysis. Students participate in polychromatic Flow and Image Cytometry experiments and will progress from Flow Cytometry analysis to cell sorting. R. Konz. Fall. 2 credits. Prerequisites: BBS 832b (which may be taken concurrently).
6. BBS 832b Introduction to Flow & Image Cytometry
The emphasis of the course is a conceptual introduction to the technical and academic aspects of Flow and Image Cytometry. The course will include guest lecturers from leaders in the field. Part one consists of lectures discussing theory, optics, fluorescence characteristics and instrumentation. Part two progresses to cell sorting, complimentary technology such as confocal microscopy and advanced applications that rely on these novel technologies.
R. Konz. Fall. 1 credit. Prerequisite: None.
7. BBS 833 Graduate Student Seminar In Immunology & Microbiology
Advanced IMP graduate students present seminars on their thesis research. Fall. 1 credit. Prerequisites: One of the following advanced courses: BBS 821, BBS 822, BBS 823 and BBS 832a and b.
8. BBS 834 lmmunobiology & Microbiology Seminar & Discussion
Leading researchers from outside the institution present a weekly seminar on a basic or clinical immunology and microbiology topic. Prior to the seminar, students read papers suggested by the seminar speaker and discuss the papers in class. Following the seminar, graduate students meet with the speaker for a discussion of the formal seminar. This course surveys the most important areas of basic and clinical immunology or microbiology including, but not limited to, antigen presentation; gene rearrangements; and expression of the genes for antigen receptors, immune tolerance, cytokines, immune cell development, immunodeficiency diseases, autoimmune diseases, human immune system malignancies and immune response to infectious agents such as viruses, parasites and bacteria. This course must be taken twice. Best taken in second and third year. F. Chan, Spring. 2 credits. Prerequisite: One of the following advanced courses: BBS 821, BBS 822, BBS 823 and BBS 832a and b.
9. BBS 846 Immunology/Virology/Bacteriology Tutorial
Recommended for students between first and second year. Students in the class will read one primary and one review paper the week before each class. The topic, paper, and review will be chosen by two student mentors. In a brief presentation, the mentors describe the current state of the field and summarize the review. The class is split into two groups, pro and con. Each group presents arguments for their opinion. The purpose is to have more discussion of positives and negatives of technique, systems and conclusions while broadening knowledge of Immunology and Microbiology. L. Berg. summer. 1 credit. Prerequisites: Core Course and BBS 755.
10. MS850 Laboratory Rotation in Immunology, Virology or Bacteriology
Laboratory rotations are defined periods of research experience under the direction of a faculty member. They are intended to familiarize the student with concepts and techniques in several areas of research and to assist the student in evaluating research laboratories and projects that might be developed into a dissertation project. Student participate in an ongoing research project, gain familiarity with concepts underlying the research, acquire a working knowledge of techniques used in the research, and write a report and present an oral summary of the results of the research. IV Faculty. 3·4 credits each.
11. MS 860 Qualifying Examination
L. Berg, T. Morrison, B. McCormick Fall, Spring, and Summer. Variable credits up to 4.
11. 900 Thesis Research in Immunology or Microbiology
IMP Faculty. Variable credits.