In House Seminars
Molecular Medicine History
2005 - 2008 - 2012
Nobel Prize Reception
Davis Royal Society Reception
Ambros Lasker Reception
Ambros Silverman Lecture
Heinrich Gottlinger, M.D., awarded 2014 Avante-Garde award
News from the National Academy of Sciences
The National Academy of Sciences has announced the election of Michael R. Green, MD, PhD, Howard Hughes Medical Institute Investigator, the Lambi and Sarah Adams Chair in Genetic Research, professor of molecular medicine and biochemistry & molecular pharmacology, and director of the Program in Gene Function and Expression, for his distinguished and continuing achievements in original research.
Jeremy Luban elected fellow of the American Academy of Microbiology
Victor Ambros named recipient of Israel's 2014 Wolf Prize.
Thomas Fazzio named one of the nations top scientists...
Foreign Policy names Luzuriaga a ‘Leading Global Thinker of 2013’ for HIV research
Dekker, Sullivan named fellows of prestigious scientific society
American Association for the Advancement of Science fellows announced
UMass Medical School scientists Job Dekker, PhD, and John L. Sullivan, MD, have been named Fellows of the American Association for the Advancement of Science (AAAS). Election as a Fellow is an honor bestowed upon AAAS members by their peers. (Full Article)
Roger Davis wins 2013 Steven C. Beering Award
The Indiana University School of Medicine Steven C. Beering Award honors an internationally recognized individual for outstanding research contributions to the advancement of biomedical or clinical science. The Beering Award was established in 1983, honoring the important contributions Dr. Beering made to the Indiana University School of Medicine as its dean from 1974 to 1983. Dr. Beering was the youngest Dean appointed to the School of Medicine. He left the School to become the president of Purdue University, serving until his retirement on August 14th, 2000. The creation of the award was announced on June 24th, 1983 and the award is presented annually and consists of a medal and a prize of $25,000. Five of the past Beering Award recipients have become Nobel laureates, either before or after receipt of this award.
2013 Awardee: Roger J. Davis, PhD
The 2013 Steven C. Beering Award was presented to Roger J. Davis, PhD, Professor of Molecular Medicine and Biochemistry & Molecular Biology at University of Massachusetts Medical School on October 30, 2013.
To view the recorded Beering lectures, please visit here
Victor Ambros wins Keio Medical Science Prize
The 18th Keio Medical Science Prize has been awarded to Victor R. Ambros, PhD, the Silverman Chair in Natural Science and professor of molecular medicine; and Shigekazu Nagata, PhD, professor of medical chemistry in the Graduate School of Medicine at Kyoto University.
Keio University annually awards the Keio Medical Science Prize “to recognize researchers who have made an outstanding contribution to the field of medicine or life sciences.”
It is the only prize of its kind awarded by a Japanese university, and six previous winners have gone on to win the Nobel Prize.
Keio Medical Science Prize Laureates will receive a certificate of merit, a medal and a monetary award at a ceremony and lecture in Tokyo on Nov. 27. - (Full article)
Katherine Luzuriaga named one of TIME magazine’s TIME 100
TIME’s annual list of the 100 most influential people in the world - link to article
Eduardo Torres Named 2013 Searle Scholar
FIFTEEN SEARLE SCHOLARS NAMED FOR 2013
April 3, 2013: Chicago, Illinois - Fifteen researchers in the chemical and biological sciences have been named as the 2013 Searle Scholars. Each will be awarded $300,000 to support his or her work during the next three years. (Full Article)
Researchers describe first 'functional HIV cure' in an infant
A team of researchers from UMMS, Johns Hopkins and the University of Mississippi have reported the first case of a so-called “functional cure” in an HIV-infected infant, which may help pave the way for eliminating HIV infection in children. (Full Article)
Bitter taste receptors in airway cells could help treat asthma attacks
UMMS research answers why substances that give some foods their bitter flavor also act to reverse the contraction of airway cells. (Full Article)
Two Molecular Medicine Scientists honored by National Academy of Inventors
January, 9 2013
Roger Davis and Craig Mello were recently named as 2012 Charter Fellows of the National Academy of Inventors (NAI). The NAI recognized 101 top scientists, innovators, and leaders from the academic world for their exceptional achievements "in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society."
The newly elected class of Fellows is made up of inventors and innovators from 56 prestigious research universities and non-profit research institutes across the U.S. and around the world. All are named inventors on patents issued by the United States Patent and Trademark Office (USPTO). Collectively, they hold an impressive number of U.S. patents—over 3,200. Dr Robert Brown and Dr John Ware from UMMS were also named as Charter Fellows.
Included among the Fellows are eight Nobel Laureates, 14 presidents of research universities and non-profit research institutes, 53 members of the National Academies (National Academy of Sciences, National Academy of Engineering, Institute of Medicine), 11 inductees of the National Inventors Hall of Fame, two Fellows of the Royal Society, five recipients of the National Medal of Technology and Innovation, four recipients of the National Medal of Science, and 31 AAAS Fellows, among other major awards and distinctions.
Roger Davis elected a Fellow of AAAS
In October, the American Association for the Advancement of Science Council elected Roger Davis, PhD, Howard Hughes Medical Institute Investigator, H. Arthur Smith Chair in Cancer Research and professor of molecular medicine and biochemistry & molecular pharmacology to the section on biological sciences. Fellows are nominated and selected by their peers for their meritorious efforts to advance science and its applications. The 701 fellows elected in 2012 will be recognized at the AAAS annual meeting in Boston in February.
Recent Molecular Medicine Publications
Role of the mixed-lineage protein kinase pathway in the metabolic stress response to obesity.
Kant S, Barrett T, Vertii A, Noh YH, Jung DY, Kim JK, Davis RJ.
Cell Rep. 2013 Aug 29;4(4):681-8. doi: 10.1016/j.celrep.2013.07.019. Epub 2013 Aug 15.
PMID: 23954791 [PubMed]
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells.
Kearns NA, Genga RM, Enuameh MS, Garber M, Wolfe SA, Maehr R.
Development. 2014 Jan;141(1):219-23. doi: 10.1242/dev.103341.
PMID: 24346702 [PubMed - indexed for MEDLINE]
Distinct functions for IFT140 and IFT20 in opsin transport.
Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ.
Cytoskeleton (Hoboken). 2014 Mar 12. doi: 10.1002/cm.21173. [Epub ahead of print] PMID: 24619649 [PubMed - as supplied by publisher]
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Serra RW, Fang M, Park SM, Hutchinson L, Green MR.
Elife. 2014 Mar 12;3:e02313. doi: 10.7554/eLife.02313.
PMID: 24623306 [PubMed]
Arf4 is required for Mammalian development but dispensable for ciliary assembly.
Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ.
PLoS Genet. 2014 Feb 20;10(2):e1004170. doi: 10.1371/journal.pgen.1004170. eCollection 2014 Feb. PMID: 24586199 (Paper)
EBV Latent Membrane Protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.
Renzette N, Somasundaran M, Brewster F, Coderre J, Weiss ER, McManus M, Greenough T, Tabak B, Garber M, Kowalik TF, Luzuriaga K. J Virol. 2014 Jan 15. (Paper)
Rab11 Endosomes Contribute to Mitotic Spindle Organization and Orientation.
Hehnly H, Doxsey S.
Dev Cell. 2014 Feb 18. pii: S1534-5807(14)00037-9. doi: 10.1016/j.devcel.2014.01.014. PMID: 24561039 (Paper)
Argonautes promote male fertility and provide a paternal memory of germline gene expression in C. elegans.
Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 (Paper)
Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology.
Udagawa T, Farny NG, Jakovcevski M, Kaphzan H, Alarcon JM, Anilkumar S, Ivshina M, Hurt JA, Nagaoka K, Nalavadi VC, Lorenz LJ, Bassell GJ, Akbarian S, Chattarji S, Klann E, Richter JD.
Nat Med. 2013 Nov;19(11):1473-7. doi: 10.1038/nm.3353. Epub 2013 Oct 20.
PMID: 24141422 [PubMed - indexed for MEDLINE] (Paper)
Gudu, an Armadillo repeat-containing protein, is required for spermatogenesis in Drosophila.
Cheng W, Ip YT, Xu Z.
Gene. 2013 Dec 1;531(2):294-300. doi: 10.1016/j.gene.2013.08.080. Epub 2013 Sep 17.
PMID: 24055424 [PubMed - indexed for MEDLINE] (Paper)
Diet-induced obesity mediated by the JNK/DIO2 signal transduction pathway.
Vernia S, Cavanagh-Kyros J, Barrett T, Jung DY, Kim JK, Davis RJ.
Genes Dev. 2013 Nov 1;27(21):2345-55. doi: 10.1101/gad.223800.113.
PMID: 24186979 [PubMed - indexed for MEDLINE] (Paper)
Argonautes Promote Male Fertility and Provide a Paternal Memory of Germline Gene Expression in C. elegans.
Conine CC, Moresco JJ, Gu W, Shirayama M, Conte D Jr, Yates JR 3rd, Mello CC.
Cell. 2013 Dec 19;155(7):1532-44. doi: 10.1016/j.cell.2013.11.032.
PMID: 24360276 [PubMed - in process]
The C. elegans CSR-1 Argonaute Pathway Counteracts Epigenetic Silencing to Promote Germline Gene Expression.
Seth M, Shirayama M, Gu W, Ishidate T, Conte D Jr, Mello CC. Dev Cell. 2013 Dec 18. pii: S1534-5807(13)00695-3. doi: 10.1016/j.devcel.2013.11.014. [Epub ahead of print] (Paper)
Using networks to measure similarity between genes: association index selection.
Fuxman Bass JI, Diallo A, Nelson J, Soto JM, Myers CL, Walhout AJ.
Nat Methods. 2013 Nov 26;10(12):1169-76. doi: 10.1038/nmeth.2728.
PMID: 24296474 Paper
Hdac6 regulates Tip60-p400 function in stem cells
Chen PB, Hung JH, Hickman TL, Coles AH, Carey JF, Weng Z, Chu F, Fazzio TG.
Elife. 2013 Dec 4;2(0):e01557. doi: 10.7554/eLife.01557.
PMID: 24302573 Paper
Absence of Detectable HIV-1 Viremia after Treatment Cessation in an Infant.
Persaud D, Gay H, Ziemniak C, Chen YH, Piatak M, Chun TW, Strain M, Richman D, Luzuriaga K.
N Engl J Med. 2013 Oct 23.
Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors.
Malaby AW, van den Berg B, Lambright DG.
Proc Natl Acad Sci U S A. 2013 Aug 12. [Epub ahead of print]
PMID: 23940353 [PubMed - as supplied by publisher] Paper
Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis.
Fazly A, Jain C, Dehner AC, Issi L, Lilly EA, Ali A, Cao H, Fidel PL, P Rao R, Kaufman PD. Chemical screening identifies filastatin, a small molecule inhibitor of Candida albicans adhesion, morphogenesis, and pathogenesis. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13594-9. Paper
Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules Kearns NA, Genga RM, Ziller M, Kapinas K, Peters H, Brehm MA, Meissner A, Maehr R. Stem Cell Res. 2013 Jun 29;11(3):1003-1012. doi: 10.1016/j.scr.2013.06.007. [Epub ahead of print] Paper
Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice.
Aouadi M, Tencerova M, Vangala P, Yawe JC, Nicoloro SM, Amano SU, Cohen JL, Czech MP.
Proc Natl Acad Sci U S A. 2013 Apr 29. Paper
A histone acetylation switch regulates H2A.Z deposition by the SWR-C remodeling enzyme.
Watanabe S, Radman-Livaja M, Rando OJ, Peterson CL.
Science. 2013 Apr 12;340(6129):195-9. Paper
CapSeq and CIP-TAP identify Pol II start sites and reveal capped small RNAs as C. elegans piRNA precursors.
Gu W, Lee HC, Chaves D, Youngman EM, Pazour GJ, Conte D Jr, Mello CC.
Cell. 2012 Dec 21;151(7):1488-500. doi: 10.1016/j.cell.2012.11.023.
PMID: 23260138 [PubMed - indexed for MEDLINE]
Efficiency of bridging-sheet recruitment explains HIV-1 R5 envelope glycoprotein sensitivity to soluble CD4 and macrophage tropism.
O'Connell O, Repik A, Reeves JD, Gonzalez-Perez MP, Quitadamo B, Anton ED, Duenas-Decamp M, Peters P, Lin R, Zolla-Pazner S, Corti D, Wallace A, Wang S, Kong XP, Lu S, Clapham PR.
J Virol. 2013 Jan;87(1):187-98. doi: 10.1128/JVI.01834-12. Epub 2012 Oct 10.
PMID: 23055568 [PubMed - indexed for MEDLINE]
HERV-H RNA is abundant in human embryonic stem cells and a precise marker for pluripotency.
Santoni FA, Guerra J, Luban J. Retrovirology. 2012 Dec 20;9(1):111. [Epub ahead of print] Paper
A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells.
Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR.
PLoS Genet. 2012 Dec; Epub 2012 Dec 20. Paper
β3-adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation.
Roth Flach RJ, Matevossian A, Akie TE, Negrin KA, Paul MT, Czech MP. J Biol Chem. 2012 Dec 12 Paper
Translational control of mitochondrial energy production mediates neuron morphogenesis.
Oruganty-Das A, Ng T, Udagawa T, Goh EL, Richter JD. Cell Metab. 2012 Dec 12 Paper
JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation.
Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ. Science. 2012 Dec 6 Paper
Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation.
D'Ambrogio A, Gu W, Udagawa T, Mello CC, Richter JD.
Cell Rep. 2012 Nov 28. doi:pii: S2211-1247. Paper
Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation.
Wang M, Amano SU, Roth Flach RJ, Chawla A, Aouadi M, Czech MP.
Mol Cell Biol. 2012 Dec 3. [Epub ahead of print] Paper
An MBoC Favorite: Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
Chen CT, Doxsey SJ.
Mol Biol Cell. 2012 Oct;23(19):3775. Paper
PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors.
Sanchez-Gurmaches J, Hung CM, Sparks CA, Tang Y, Li H, Guertin DA.
Cell Metab. 2012 Sep 5;16(3):348-62. Paper
Transcription factor ATF5 is required for terminal differentiation and survival of olfactory sensory neurons.
Wang SZ, Ou J, Zhu LJ, Green MR.
Proc Natl Acad Sci U S A. 2012 Oct 22. Paper
An Unusual Two Step Control of CPEB Destruction by Pin1.
Nechama M, Lin CL, Richter JD. Paper
Mol Cell Biol. 2012 Oct 22.
JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate.
Hübner A, Mulholland DJ, Standen CL, Karasarides M, Cavanagh-Kyros J, Barrett T, Chi H, Greiner DL, Tournier C, Sawyers CL, Flavell RA, Wu H, Davis RJ.
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12046-51. Paper
Molecular Medicine Awards
Welcome to Molecular Medicine...
Dr. Jeremy Luban joins the Program in Molecular Medicine Faculty
Drs. Amy Walker, Rene Maehr, Manuel Garber and Eduardo Torres.
Assistant Professor Michael Lee
Dr Juleen R. Zierath joins Molecular Medicine as Adjunct Professor
Juleen R. Zierath is presently Professor of Clinical Integrative Physiology and Head of the Section of Integrative Physiology at the Department of Molecular Medicine and Surgery and the Department of Physiology and Pharmacology at Karolinska Institutet, Stockholm Sweden, where she is Director of the The Strategic Research Programme in Diabetes. She is also Professor of Integrative Physiology at University of Copenhagen, where she is a Scientific Director at the Marie Krogh Center for Metabolic Research, Copenhagen Denmark.