Patients who are currently suffering from depression with irrational worries are invited to participate in a research study to determine how long people need to stay on an antipsychotic medication after they recover from their symptoms. Study participation will last up to 20 weeks and patients will receive a combination of an antipsychotic medication and an antidepressant medication. Participants must be: 18 – 85 years of age; experiencing symptoms of depression with irrational worries; not be pregnant. Participants will receive study medication and study-related care at no cost. For more information please contact: Chelsea Kosma at (508) 856-5312.