Section: Research

John Mordes, M.D.

	Board Certification	American Board of Internal Medicine American Board of IM-Endocrinology, Diabetes, Meta
	Medical Degree	Harvard Medical School Boston  Massachusetts
	Residency/Training	Brigham & Women's Hospital Massachusetts Mental Health Center
	Fellowship	UMass Memorial Medical Center

Research

Our laboratory conducts basic and clinical research in the area of type 1 diabetes. Basic research is currently focused on the genetics and pathophysiology of diabetes in rat models of the disease with particular emphasis on the T cell receptor beta chain and the diubiquitin gene. We are also in the early stages of a program designed to understand the mechanisms underlying type 1 diabetes following viral infection. Another program is studying the susceptibility of certain rats to multiple disorders including diabetes, arthritis, and thyroiditis. Finally, we are also participating in clinical studies of otelixizumab, an anti-CD3 monoclonal antibody currently in phase 3 trials in adolescents and adults with new onset type 1 diabetes and in clinical studies of non-invasive methods for measuring glucose concentration.

Office: LRB 222
Phone: 508-856-3166
E-mail: John.Mordes@umassmed.edu
Keywords: Immunology, Autoimmunity, Cell Biology, Genetics, Diabetes

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