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William Theurkauf, Ph.D.Academic Role: Professor
Faculty Appointment(s) In:
Other Affiliation(s):
Mutations in the Drosophila scrambled locus disrupt mitotic actin organization
and function. Drosophila embryogenesis is initiated by 13 rapid nuclear divisions
that proceed without cytokinesis. During the final four syncytial divisions, when most
of the nuclei are in a monolayer at the surface of the embryo, actin (green) associates
with membrane furrows that surround the mitotic spindles (red). In scrambled
mutant embryos, the actin furrows do not form and interactions between neighboring spindles
lead to chromosome segregation errors. To define the molecular mechanisms that drive
actin reorganization, we are using genetic and biochemical techniques to identify proteins
that function with scrambled during mitotic furrow assembly.
Office: Bio4 312E
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55 Lake Avenue North Worcester, MA 01655