Section: Research

Thoru Pederson, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Vitold Arnett Professor of Cell Biology

RNA traffic in eukaryotic cells, RNA processing, RNA-protein interactions, siRNA

We are investigating the functional significance of specific protein-RNA interactions in eukaryotic gene expression, with particular emphasis on RNA traffic and processing.  We have also been combining in situ RNA detection methods with novel approaches we have developed for following fluorescent RNA molecules in living mammalian cells.  One current focus is the assembly of the signal recognition particle.  We are also studying the transport of various RNAs within the nucleus (see video link below).  Another major project concerns novel functions of the nucleolus (beyond its role in ribosome production), with particular emphasis on cell cycle progression and checkpoints.

Office: B4-337
Phone: 508-856-8667
Fax: 508-856-8668
E-mail: Thoru.Pederson@umassmed.edu
Keywords: RNA Biology, Stem Cell Biology, Gene Expression, Nuclear Architecture, RNA Interference (RNAi)

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