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Stephen Doxsey, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Program in Molecular Medicine

Joint Faculty In:
   Biochemistry and Molecular Pharmacology

Other Affiliation(s):
   Cell Biology
   Cell Dynamics Group
   Interdisciplinary Graduate Program

Recent Publications

Doxsey, S.J. Re-evaluating centrosome function.  Nature Rev., Molec Biol. 2, 688-699, 2001.

Pihan, G., Zhou, Y., Wallace, J., Zhou, Y. and Doxsey, S.  Centrosome abnormalities and genetic instability occur together in precancerous lesions.  Cancer Res., 63, 1398-1404, 2003.

Gromley, A., Jurczyk, A., Sillibourne, J., Halilovic, E., Mogenson, M., Groisman, I., Blomberg, M., and Doxsey, S.  A novel human protein of the maternal centriole is required for the final stages of cytokinesis and entry into S phase.  J. Cell Biol, 161, 535-545, 2003.

Pihan, G. and Doxsey, S.  Mutations and aneuploidy:  Co-conspirators in cancer?  Cancer Cell 4, 89-94, 2003.

Chen, D., Purohit, A., Halilovic, E., Doxsey, S., Newton, A.  Protein kinase C anchoring at the centrosome controls cytokinesis.  J. Biol. Chem., 279, 4829, 2004.  (cover photo)

Jurczyk, A., Gromley, A., Redick, S., San Augustin, J., Witman, G., Pazour, G., Peters, J.M. and Doxsey, S.  Pericentrin is required for primary cilia assembly and anchoring intraflagellar transport proteins at basal bodies.  J. Cell Biol. 166,637-643, 2004.

Gavanescu, I., Pihan, G., Halilovic, E., Szomolanyi-Tsuda, E., Welsh, R., and Doxsey, S.  Mycoplasma infection induces a scleroderma-like centrosome autoantibody response in mice.  Clin. Exp. Immun. 137, 288-297, 2004.

Doxsey, S., Zimmerman, W., Mikule, K.  Centrosome control of the cell cycle.  Trends Cell Biol. 15, 303-311, 2005.

Gromley A, Yeaman C, Rosa J, Redick S, Chen C, Mirabelle, S, Guha, M and Doxsey S. Centriolin-anchoring of exocyst and SNARE complexes at the midbody is required for secretory vesicle-mediated abscission. Cell 123, 75-87, 2005.

Doxsey S, Zimmerman S, Mikule K.  Centrosome control of the cell cycle.  Trends Cell Biol. 15, 303-311, 2005.

Doxsey S, McCollum D, Theurkauf, W.  Centrosomes in cellular regulation.  Ann Rev Cell Dev Biol, 21, 411-434, 2005.

Doxsey, S. Molecular links between centrosome and midbody. Molecular Cell, 20, 170-172, 2005.

Mikule K, Delaval B, Kaldis P, Jurczyk A, Hergert P, Doxsey S.  Loss of centrosome integrity induces p38-p53-p21-dependent G1-S arrest.  Nat Cell Biol. Feb 9(2): 160-70, 2007.

Office: Biotech II-Suite 210
Phone: 508-856-1613
E-mail: Stephen.Doxsey@umassmed.edu
Keywords: Cancer Biology, Cell Biology, Biochemistry

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