Core Facilities

Electron Microscopy Core Facility

EM scopeDirected by Roger Craig, PhD, and George Witman, PhD, and managed by Greg Hendricks, PhD. The facility is equipped with one scanning and three transmission electron microscopes together with the ancillary equipment required to carry out all key ultrastructural procedures from the tissue to the molecular level. The facility provides full service in specimen preparation, microscopy and interpretation of results, all at very reasonable rates. Training and use of all the equipment are also available and encouraged.http://www.umassmed.edu/cemf/

Transgenic and Knock-out Mouse Core Facility

Mouse CoreDirected by Stephen Jones. Gene Targeting component is supervised by Marilyn Keehler. Animal knock-out component is managed by Joe Gosselin. The mission of the Transgenic Animal Modeling Core is to produce genetically-altered mice for the UMASS Medical School Community in a timely and cost-efficient manner. In the last eight years the Core has generated more than 300 different lines of transgenic mice, targeted over 60 genes in mouse ES cells, produced over 120 lines of gene-targeted mice via blastocyst injection, and has cryopreserved over 100 lines of mice for UMASS researchers. http://www.umassmed.edu/tkomouse

Confocal Core Facility

3DML confocal coreThe Cell and Developmental Biology Three-Dimensional Microscopy Laboratory (3DML) is designed to provide excellent laser scanning confocal microscopy equipment, training, and technical support to the UMass Medical School research community. Investigators new to confocal microscopy may participate in a training course. Trained or experienced investigators may contact us to schedule time on our Leica TCS SP5 II laser scanning confocal microscope with AOBS (Acousto-Optical Beam Splitter), spectrophotometric detection, and a 405nm laser. http://www.umassmed.edu/3dml/

International Stem Cell Registry

StemCellThe International Stem Cell Registry (ISCR) is a freely accessible, continuously updated, searchable database for the stem cell research community. The most comprehensive database on human embryonic stem cell (hESC) and disease-specific induced pluripotent (iPS) stem cell lines, the ISCR currently provides published and validated unpublished information for over 1,500 cell lines from over 20 countries. The ISCR also includes a literature database of over 1,600 citations that are searchable by cell line name and keywords in the abstract.   http://www.umassmed.edu/iscr/index.aspx