Lisa Hall Ph.D.
Assistant Professor, 2002-Present
BA: The Colorado College, Biology, 1988
PhD: Univ. California-Davis, Genetics, 1996
Lisa Hall was born and raised in Hawaii. She got her BA in Biology from The Colorado College, where she became interested in human clinical genetics. She earned her PhD in Molecular Genetics from the University of California-Davis, with an emphasis on human and cancer genetics. Lisa became an Assistant Research Professor at UMMS in 2005, and has was the assistant director for the human medical genetics course from 2002-2010. She is a co-investigator with Dr. Jeanne Lawrence on numerous research projects pertaining to nuclear structure and epigenetic regulation of the genome. Lisa’s initial interest in this area began with studying how long non-coding RNAs interact with chromatin (e.g. Xist RNA and the inactive X-chromosome), and the role these molecules play in gene regulation. This has now expanded to include changes in heterochromatin formation and nuclear structure in carcinogenesis, hESC differentiation and reprogramming (iPS cell formation), as well as our new project on silencing the extra chromosome 21 in Down syndrome patient cells using a ZFN-targeted XIST transgene (Jiang et al 2013, Nature).
Jun Jiang, M.D., Ph.D.
MD: China Medical University, Pediatrics, 1990
PhD: China Medical University, Molecular Genetics of Pediatrics, 2005
Jun Jiang received her M.D. from China Medical University. She had practiced medicine specialized in childhood developmental and genetic diseases for ten years. During her practice, she gained firsthand clinical experience, but also realized that a better understanding of diseases at the molecular level was critical for proper diagnosis and treatment of these diseases. Her Ph.D study was centered on molecular mechanisms of a number of childhood genetic disorders. In addition, she had spent another four years studying the molecular mechanisms of neuronal axon growth and guidance. Since 2009, she has been working on the high-risk Down’s syndrome “chromosome therapy” project as a senior researcher in Dr. Jeanne B. Lawrence’s lab for four years and her extensive experience on human genetics and neuroscience has helped her make a substantial contribution to the "chromosome therapy" project. Using zinc finger nuclease technology, she has successfully inserted an inducible, large XIST transgene into Chromosome 21 in induced pluripotent stem (iPS) cells derived from a Down’s syndrome patient, which results in chromosome-wide transcriptional silencing of the extra Chromosome 21. Successful trisomy silencing in vitro surmounts the major first step towards potential development of “chromosome therapy” (Jiang et al 2013, Nature).
Dawn Carone Ph.D.
Postdoctoral Fellow, 2009-Present
BS: University of Connecticut, Molecular and Cell Biology, 2004
PhD: University of Connecticut, Genetics and Genomics, 2008
Research Associate, 1993-Present
BA: Framingham State College, 1996
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Research Lab Tech I, 2012-Present
BS: Shenyang Institute of Technology, 1991
Graduate Student, 2009-Present
BS: University of Wisconsin, Biochemistry, 2008
Graduate Student, 2010-Present
BA: Connecticut College, 2002
Jen-Chieh Chiang (Jay)
Graduate Student, 2011-Present
MS: New York University, Biology, 2010
BS: Taipei Medical University, 2007
Project Coordinator and Adminstrative Secretary to the Department Chair
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