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Hong Zhang, Ph.D.
Academic Role: Assistant Professor
Faculty Appointment(s) In:
Cell Biology
Other Affiliation(s):
Interdisciplinary Graduate Program
Publications
Zhang, H.*, Teng, Y., Kong, Y., Kowalski, P.E., and Cohen, S.N. (2008). Suppression of human tumor cell proliferation by Smurf2-induced senescence. J. Cell. Physiol. In press (* correspondence author)
Zhang, H. (2007). Molecular signaling and genetic pathways of senescence: its role in tumorigenesis and aging. J. Cell. Physiol. 210, 567-574.
Zhang, H., and Cohen, S. N. (2004). Smurf2 up-regulation activates telomere dependent senescence. Genes & Dev. 18, 3028-3040.
Zhang, H., Herbert, B. S., Pan, K. H., Shay, J. W., and Cohen, S. N. (2004). Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene 23, 6193-6198.
Zhang, H., Pan, K. H., and Cohen, S. N. (2003). Senescence-specific gene expression fingerprints reveal cell-type- dependent physical clustering of up-regulated chromosomal loci. Proc. Natl. Acad. Sci. USA 100, 3251-3256.
Li, Z., Zhang, H., McManus, T. P., McCormick, J. J., Lawrence , C. W., and Maher, V. M. (2002). hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts. Mutat. Res. 510, 71-80.
Zhang, H., Marra, G., Jiricny, J., Maher, V. M., and McCormick, J. J. (2000). Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts. Carcinogenesis 21, 1639-1646.
Zhang, H., Tsujimura, T., Bhattacharyya, N. P., Maher, V. M., and McCormick, J. J. (1996). O6-methylguanine induces intrachromosomal homologous recombination in human cells. Carcinogenesis 17, 2229-2235.
Office: S7-125
Phone: 508-856-5423
E-mail: Hong.Zhang@umassmed.edu
Keywords:
Cancer,
Aging,
Mouse Models,
Metastasis
Postdoctoral Position Available
Postdoctoral Position Available
A postdoctoral fellow position is available in the Zhang laboratory. Areas of study include the molecular mechanisms of senescence and its functions in cancer and aging. Both cell culture and mouse models are used. A Ph.D. in molecular and cellular biology, genetics, or a related field is required. Prior experience in cell culture and mouse genetics is desirable. Please send curriculum vitae to Dr. Zhang (hong.zhang@umassmed.edu).
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