Section: Rotations

Janet Stein, Ph.D.

Academic Role: Professor

Faculty Appointment(s) In:
   Cell Biology

Potential Rotation Projects

Project #1: HiNF-P in regulation of H4 histone gene transcription
HiNF-P is a critical factor that interacts with the proximal cell cycle regulatory element of the H4 histone gene. We have isolated a protein that possesses HiNF-P binding activity on the H4 promoter. This protein is a candidate for a key role in regulating H4 transcription during the cell cycle. To determine its biological activity, we will use molecular, biochemical and cellular approaches, including transfection and overexpression analyses coupled with immunofluorescence microscopy.

Project #2: Chromatin structure of an osteoblast-specific gene
Chromatin immunoprecipitation assays will be used to examine the dynamics of regulatory protein interactions with the promoter of the bone-related osteocalcin gene as expression is activated during osteoblast differentiation.

Office: S3-310
Phone: 508-856-4996
E-mail: Janet.Stein@umassmed.edu
Keywords: Stem Cell Biology, Cancer Biology, Cell Biology, Cell Cycle, Gene Regulation

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